grant
Gene Expression and Manipulation Core
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 1 May 1997Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025Alternate SplicingAlternative RNA SplicingAlternative SplicingAntimorphic mutationApplications GrantsAreaBasic ResearchBasic ScienceBiochemistryBiologicalBiological ChemistryBiomedical ResearchBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCellsCellular biologyCharacteristicsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCore FacilityDNADNA Molecular BiologyDNA seqDNA sequencingDNAseqDataDeoxyribonucleic AcidDiseaseDisorderDominant NegativeDominant-Negative MutantDominant-Negative MutationELISAEnzyme-Linked Immunosorbent AssayExperimental DesignsExpression SignatureEyeEyeballFoundationsFundingFutureGene ExpressionGene Expression ProfileGene ProteinsGene SplicingGene TransferGenesGeneticGenetic studyGrant ProposalsHuman ResourcesImmunoblottingIndividualInfectionIntentionInvestigationInvestigatorsLentivirinaeLentivirusLinkManpowerMeasuresMediatingMessenger RNAMethodsModernizationModificationMolecularMolecular BiologyOphthalmologyOutcomePost-Transcriptional Gene SilencingProcessProgenitor CellsPropertyProtein Gene ProductsProteinsQuantitative RTPCRQuantitative Reverse Transcriptase PCRR-Series Research ProjectsR01 MechanismR01 ProgramRNA InterferenceRNA SeqRNA SilencingRNA sequencingRNAiRNAseqRecombinantsResearchResearch DesignResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersSamplingSequence-Specific Posttranscriptional Gene SilencingServicesSightSpinal ColumnSpineSpliced GenesStudy TypeTechniquesTimeTissuesTransfectionValidationVertebral columnViralViral GenesVisionWestern BlottingWestern Immunoblottingbackbonebase editingbehavior changebiologiccell biologycompare treatmentcost effectivedeliver mRNAdeliver messenger RNAdelivery system for mRNAdisease modeldisorder modelenzyme linked immunoassayexperiencefallsgene editing methodgene editing methodologygene editing strategygene editing techniquesgene expression patterngene expression signaturegene manipulationgene-editing approachgenetic manipulationgenetically manipulategenetically perturbinnovateinnovationinnovativeinstrumentinstrumentationknock-downknockdownlaser capture microdissectionlipid based nanoparticlelipid nanoparticlemRNAmRNA deliverymessenger RNA deliverymutantoverexpressoverexpressionpersonnelprime editingprotein blottingqRTPCRstem cellsstudy designsuccesstranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtreatment comparisontreatment effecttreatment groupvalidationsvectorvision sciencevisual functionvisual science
Description preview
PROJECT SUMMARY - GENE EXPRESSION & MANIPULATION
The Gene Expression & Manipulation core is focused on providing support and assisting and facilitating specific
studies relating to gene expression and manipulation. Most of the types of studies supported by this core fall
within the range of ocular molecular biology, biochemistry, and cell biology.…
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