grant
Gallium maltolate for the treatment of difficult-to-treat high-grade pediatric brain tumors
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAddressAdultAdult GlioblastomaAdult Glioblastoma MultiformeAdult HumanAdverse effectsAgreementAnimalsAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAssayAutoregulationBehaviorBehavior assessmentBioassayBioavailabilityBioenergeticsBiological AssayBiological AvailabilityBiological MarkersBiologyBiopsyBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesBrainBrain CancerBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCD71CNS CancerCNS Nervous SystemCNS TumorCNS neoplasmCancer DrugCancersCategoriesCause of DeathCell DeathCell LineCell surfaceCellLineCentral Nervous SystemCentral Nervous System CancerCentral Nervous System NeoplasmsCentral Nervous System TumorsChildChild YouthChildhoodChildhood Brain NeoplasmChildhood Brain TumorChildhood CNS NeoplasmChildhood CNS TumorChildhood Central Nervous System NeoplasmChildhood Central Nervous System TumorChildhood GliomaChildhood Malignant Brain TumorChildhood Solid NeoplasmChildhood Solid TumorChildren (0-21)ChronicCombined Modality TherapyCommon Rat StrainsComplementComplement ProteinsCoupledDIPGDataDiffuse intrinsic pontine gliomaDiffusionDoseEffectivenessEncephalonEvaluationFe elementFe metabolismGa elementGalliumGeneralized GrowthGenerationsGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Adult Astrocytic NeoplasmGrade IV Adult Astrocytic TumorGrade IV Adult AstrocytomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrowthHeartHepaticHeterograftHeterologous TransplantationHomeostasisICP-MSIn VitroInductively Coupled Plasma Mass SpectrometryInflammatoryIntermediary MetabolismInvestigationIronKidneyKidney Urinary SystemKnowledgeLiverLytotoxicityMR ImagingMR SpectroscopyMR TomographyMRIMRIsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalignant CNS NeoplasmsMalignant CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant Tumor of the CNSMalignant Tumor of the Central Nervous SystemMalignant neoplasm of brainMalignant neoplasm of central nervous systemMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolic ProcessesMetabolismModalityModelingMolecularMonitorMotorMultimodal TherapyMultimodal TreatmentNMR ImagingNMR TomographyNeoplastic Disease Chemotherapeutic AgentsNeuraxisNeuroglial NeoplasmNeuroglial TumorNormal CellNormal TissueNormal tissue morphologyNuclear Magnetic Resonance ImagingOralOutcomeOxidation-ReductionPathway interactionsPatientsPediatric GliomaPediatric Malignant Brain TumorPediatric Solid TumorPediatric high-grade gliomaPerfusionPhysiologic AvailabilityPhysiological HomeostasisPlasmaPlasma SerumPlayPredispositionPrimary Brain NeoplasmsPrimary Brain TumorsProcessPrognosisQOLQOL improvementQuality of lifeRadiation SensitizersRadiation therapyRadiation-Sensitizing AgentsRadiation-Sensitizing DrugsRadiosensitizing AgentsRadiosensitizing DrugsRadiotherapeuticsRadiotherapyRadiotherapy sensitizerRatRats MammalsRattusReactionRedoxRelapseRenal functionResearchResearch SpecimenReticuloendothelial System, Serum, PlasmaRhabdoid SarcomaRhabdoid TumorRoleScheduleSeriesSpecimenSpinal ColumnSpineStrains Cell LinesSusceptibilityTFR geneTFR proteinTFR1TFRCTFRC geneTRFRTestingTherapeuticTherapeutic IndexTherapeutic InterventionTimeTissue GrowthTissuesToxic effectToxicitiesTransferrin ReceptorTransferrin Receptor 1Treatment ProtocolsTreatment RegimenTreatment ScheduleTumor CellTumor-Specific Treatment AgentsVertebral columnXenograftXenograft procedureXenotransplantationZeugmatographyadulthoodanti-cancer drugbackbonebehavioral assessmentbio-markersbiologic markerbiomarkerbrain tissuecancer cellcancer of the central nervous systemchild patientschildhood brain cancerclinical translationclinically translatablecohortcombination therapycombined modality treatmentcombined treatmentcomplementationcultured cell linecytokinecytotoxiccytotoxicitydetermine efficacydevelop therapydiffuseddiffusesdiffusingdiffusionsdrug discoveryefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyglial-derived tumorglioblastoma multiformehepatic body systemhepatic organ systemimprovedimprovements in QOLimprovements in quality of lifein vivoinsightintervention developmentintervention therapyiron metabolismkidney functionkidslife spanlifespanmalignancymimeticsmortalitymulti-modal therapymulti-modal treatmentnecrocytosisneoplasm/cancerneoplastic cellneuroglia neoplasmneuroglia tumorneurotoxicnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyoxidation reduction reactionpathwaypatient populationpediatricpediatric CNS neoplasmpediatric CNS tumorpediatric brain cancerpediatric brain neoplasmpediatric brain tumorpediatric central nervous system neoplasmpediatric central nervous system tumorpediatric patientsquality of life improvementradiation effectradiation treatmentradiosensitizerrenalresponseresponse to therapyresponse to treatmentsocial rolespongioblastoma multiformesurvival outcometargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy developmenttherapy responsetraffickingtreatment developmenttreatment effecttreatment responsetreatment responsivenesstreatment with radiationtrendtumortumor growthtumor of the central nervous systemtumor xenografttumors in the braintumors in the central nervous systemuptakexeno-transplantxeno-transplantationyoungster
Description preview
PROJECT ABSTRACT/SUMMARY
Neoplasms of the central nervous system (CNS) are the most frequently encountered solid tumors of childhood
and remain one of the top causes of death in children. Pediatric high-grade gliomas (pHGGs) and atypical
teratoid rhabdoid tumor (ATRT) are particularly aggressive pediatric CNS (pedCNS) tumors associated with
poor…
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