grant
Galectin-3 and corneal nerve regeneration
Organization TUFTS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025Adverse effectsAfferent NeuronsAffinityAnatomic SitesAnatomic structuresAnatomyAnimal LectinsAnimal ModelAnimal Models and Related StudiesAreaBindingBiologyCBP-30CBP-35CBP35CNS Nervous SystemCarbohydrate-Binding Protein 35CarbohydratesCell BodyCell Communication and SignalingCell SignalingCell SurvivalCell ViabilityCell membraneCell surfaceCellsCentral Nervous SystemChemicalsClinicalCorneaCorneal DiseasesCorneal DisorderCorneal UlcerCytoplasmic MembraneD-Galactoside-Binding LectinDataDegenerative DisorderDegenerative Neurologic DisordersDevelopmentDiagnostic FindingsDry Eye SyndromesDry eye diseaseEpithelial CellsEpsilon-Binding ProteinEsthesiaEventEyeEye DropsEyeballEyedropsFamilyFood and Drug AdministrationGP80-LNGFRGalactose Binding LectinGalaptinsGalectin 3GalectinsGasser's GanglionGasserian GanglionGeneralized GrowthGeneticGliaGlial CellsGlycoproteinsGrowthGrowth AgentsGrowth FactorGrowth SubstancesHL-29IgE Binding ProteinIgEBPImpairmentIn VitroIntracellular Communication and SignalingKeratitisKeratoconjunctivitis SiccaKeratopathyKolliker's reticulumL-29 LectinL-31L-34L30 LectinLGALS3Lacrimal deficiencyLigandsLiquid substanceLocationLow-Affinity Nerve Growth Factor ReceptorMac-2 AntigenMacrophage-2 AntigenMaxillaMechanicsMethodsMiceMice MammalsMolecular InteractionMurineMusNGF ReceptorNGF ReceptorsNGFR ProteinNerveNerve CellsNerve Growth Factor ReceptorNerve Growth Factor Receptor p75Nerve Growth Factor ReceptorsNerve Growth FactorsNerve PlexusNerve RegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural PathwaysNeural degenerative DisordersNeuraxisNeuritesNeuro-regenerationNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeuronotrophic FactorsNeuronsNeuropeptidesNeuroregenerationNeurotrophic Factor ReceptorNeurotrophic KeratitisNeurotrophic ProteinsNeurotrophin ReceptorsNeurotropin Receptor p75Non-neuronal cellNonneuronal cellNutrientOcular desiccationPathogenesisPathologicPatientsPeripheralPhysiologicPhysiologicalPlasma MembranePlayProtein GlycosylationProteins Growth FactorsReceptor ProteinRecombinantsRecoveryRegulationResearchRoleS-Type LectinsSemilunar GanglionSensationSensory NeuronsSensory ProcessSignal TransductionSignal Transduction SystemsSignalingSigns and SymptomsStructureStructure of trigeminal ganglionSurfaceTestingTherapeuticTissue GrowthTopical Drug AdministrationTopical applicationTrigeminal GangliasTrigeminal GanglionTrigeminal SystemUSFDAUlcerative KeratitisUnited States Food and Drug AdministrationViralanalogapply topicallyaxon regenerationaxonal regenerationbeta-D-Galactosyl-Specific Lectinbeta-Galactoside Binding Lectinbiological signal transductioncarbohydrate binding proteincarbohydrate receptorcornea disordercornea ulcercornealcorneal epithelialcorneal epitheliumcorneal healingcorneal regenerationcorneal ulcerationcrosslinkdefined contributiondegenerative conditiondegenerative diseasedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdeliver topicallydensitydevelopmentaldry eyeeye drynessfluidgp75 NGFRimprovedin vivoinjury recoveryinnervationintraepithelialliquidmaxillarymechanicmechanicalmembermodel of animalnerve cementnerve injurynerve supplynervous system regenerationneural injuryneural mechanismneural regenerationneurodegenerative illnessneuromechanismneuronalneuroregenerativeneurotrophic factorneurotrophinneutrophinnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachocular drynessocular signs of drynessocular surfaceocular surface diseaseocular surface disorderocular surface drynessontogenyp75 neurotrophin receptorp75NTRplasmalemmapreservationprotein bound carbohydrateprotein expressionreceptorrecovery after injuryrecovery following injuryrecovery post injuryregenerated nervereinnervatereinnervationresponseside effectsocial roletear deficiencytherapeutic targettopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttranscriptional reprogrammingtreat topicallytrigeminal
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Project Summary/Abstract
The avascular cornea is innervated by a dense network of sensory processes derived from the ophthalmic and
maxillary regions of the trigeminal ganglion. Corneal nerves provide not only mechanical, chemical, and thermal
sensitivity to the front of the eye but also release nutrients and trophic factors that supply the…
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