grant
GABAergic Circuit Targets for Modulating Entorhinal Cortex and Hippocampal Dynamics in Alzheimer's Disease
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 15 Jan 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY20262-photonAD dementiaAD modelAD pathologyAD patientsAD therapyAD treatmentAcetylcholineAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease therapeuticAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's patientAlzheimer's therapeuticAlzheimer's therapyAlzheimers DementiaAmericanAmmon HornAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAreaAtrophicAtrophyAutopsyAβBedsBehaviorBehavioralBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemCB1CB1 ReceptorCB1RCCKCNR1 geneCannabinoid Receptor CB1CannabinoidsCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCholecystokininChronicClinicalCodeCoding SystemCognitionCognitiveCognitive DiscriminationCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCollaborationsConnector NeuronCornu AmmonisCuesCyclic SomatostatinDataDegenerative Neurologic DisordersDendritesDiscriminationDiseaseDisinhibitionDisorderDisturbance in cognitionDysfunctionElectrophysiologyElectrophysiology (science)ElementsEncephalonEncephalon DiseasesEntorhinal AreaExerciseFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGeneticGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHippocampusHumanImageImpaired cognitionImpairmentIn VitroIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationKI miceKnock-in MouseKnowledgeLateralLinkMT-bound tauMapsMeasuresMediatingMemoryMemory DeficitMemory LossMemory impairmentMiceMice MammalsMicroscopyModern ManMolecularMurineMusNerve CellsNerve DegenerationNerve Transmitter SubstancesNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyNeurotransmittersNicotineOdorsOlfactory dysfunctionOutcomeOutputPHM27PancreozyminPathologicPathway interactionsPatientsPerformancePhysiciansPhysiologicPhysiologicalPhysiopathologyPredispositionPrimary Senile Degenerative DementiaProteinsProteomicsProxyPyramidal neuronRewardsSRIHSRIH-14SamplingScientistSensorySliceSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSubcellular ProcessSusceptibilitySymptomsSynapsesSynapticSynaptic ReceptorsSystemTestingTherapeuticTissuesUropancreozyminVasoactive Intestinal PeptideVasoactive Intestinal PolypeptideVasointestinal Peptidea beta peptideabetaagedalzheimer modelamyloid betaamyloid-b proteinawakebehavioral impairmentbeta amyloid fibrilbrain cellbrain tissuecannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1cell typecellular targetingcholinergiccognitive defectscognitive dysfunctioncognitive functioncognitive lossdegenerative diseases of motor and sensory neuronsdegenerative neurological diseaseselectrophysiologicalentorhinal cortexexperienceexperimentexperimental researchexperimental studyexperimentsfMRIgrowth hormone release inhibiting factorhippocampalhippocampal pyramidal neuronimagingimpaired behaviorimprovedin vitro activityin vivoin vivo two-photon imaginginhibitory neuronknockin micememory declinememory dysfunctionmicrotubule bound taumicrotubule-bound taumild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmouse modelmurine modelnecropsyneuralneural circuitneural circuitryneural controlneural degenerationneural networkneural regulationneurocircuitryneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological degenerationneuromodulationneuromodulatoryneuronalneuronal degenerationneuropathologicneuropathologicalneuropathologyneuroprotectionneuroprotectiveneuroregulationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyolfactory impairmentpathophysiologypathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADpostmortempostsynapticpreventpreventingprimary degenerative dementiaresilienceresilientresponsesenile dementia of the Alzheimer typesoluble amyloid precursor proteinspatial memorysynapsesynaptic circuitsynaptic circuitrytangletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau Proteinstau factortherapeutic targettranslational opportunitiestranslational potentialtwo-photonτ Proteins
Description preview
Project Summary:
Alzheimer’s disease (AD) patients, even in the mild cognitive impairment stage, show pronounced memory impairment
that correlates with AD pathology in the entorhinal cortex (EC) - hippocampus circuit. Within the EC-hippocampal
network, the lateral EC (LEC) and hippocampal area CA1 are most susceptible. Yet, there is a gap in our…
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