grant
GABAergic Cells in the Periaqueductal Gray Region Control Food-Seeking
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 19 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AffectAnorexiaAppetiteAppetitive BehaviorAssayAxonBehaviorBehavior ControlBehavioral ManipulationBinge EatingBinge eating disorderBioassayBiologicalBiological AssayCell BodyCellsClinicalCollaborationsComputing MethodologiesConsumptionCricketsDataDedicationsDesire for foodDisinhibitionDissectionEatingEating DisordersExposure toFearFeeding behaviorsFoodFood IntakeFrightFutureGryllidaeHealthHuman ResourcesHydrogen OxideIngestive BehaviorInsectaInsectsInsects InvertebratesInvestigatorsLateralLinkMaintenanceManpowerMesencephalic Central GrayMesencephalonMetabolicMiceMice MammalsMicroscopeMid-brainMidbrainMidbrain Central GrayMidbrain structureModalityMolecularMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsObesityOpticsOutcomePathway interactionsPatternPeriaqueductal GrayPopulationPublicationsReportingResearch PersonnelResearchersRoleScientific PublicationSliceSourceStimulusSymptomsSynapsesSynapticTestingWateradiposityannulus of the aqueductapproach behaviorbehavioral controlbiologiccompulsive eatingcompulsive feedingcompulsive overeatingcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcorpulencefeedingfeeding-related behaviorshedonicin vivoinsightmidbrain central gray substanceminiaturizeminiaturizedneuralneural controlneural regulationneuromodulationneuromodulatoryneuronalneuroregulationnovelnutrient intake activityopticaloptogeneticspathwayperiaqueductal gray matterpersonnelsocial rolesynapsetoolzona incerta
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Project Summary/Abstract
Abnormalities in feeding behaviors are a key symptom of several conditions, including binge-eating disorder,
anorexia and obesity. In order to develop novel treatments, it is imperative to gain a deeper understanding of the
circuits controlling adaptive feeding. Eating is affected by metabolic and hedonic features, and it…
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