grant
G4 in Aging at Organismal Level
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAgeAgingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBody TissuesCell BodyCellsClass SwitchingClass SwitchingsDNADNA DamageDNA HelicasesDNA InjuryDNA ReplicationDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA metabolismDNA unwinding enzymeDeoxyribonucleic AcidDisease ProgressionDrosophilaDrosophila genusEnsureEnzyme GeneEnzymesG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGene TranscriptionGenesGeneticGenetic TranscriptionGenetics-MutagenesisGenomic DNAHereditaryImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsImmunoglobulin Isotype-Switch RecombinationImmunoglobulin Switch RecombinationIn VitroInheritedIsotype SwitchingIsotype SwitchingsLiver RegenerationLong-term cohort studyLongitudinal cohort studyMiceMice MammalsModelingMurineMusMutagenesisMutagenesis Molecular BiologyMutateNucleic AcidsOrganismPathologyPathway interactionsPremature AgingPremature aging syndromeProliferatingProteinsRNA ExpressionRNA metabolismResolutionRoleSwitch RecombinationTissuesTranscriptionTranslationsWorkage associated declineage associated diseaseage associated disorderage associated impairmentage dependent declineage dependent diseaseage dependent disorderage dependent impairmentage related declineage related human diseaseage-related diseaseage-related disorderage-related impairmentagedaged miceaged mouseagesaging associatedaging associated diseaseaging associated disordersaging relatedaging related diseaseaging related disordersarmdecline with agedisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingelderly micefruit flygDNAgene producthelicaselife spanlifespanliving systemmutantnatural agingnormal agingnormative agingold micepathwayregeneration modelregenerative modelrepairrepairedreproductive organresolutionssocial roletranslation
Description preview
We will investigate the role of G4 in organismal aging using two models; mouse and fruit fly. For the mouse work, the aging cohort Study of Longitudinal Aging in Mice (SLAM) and mouse liver regeneration model will be utilized to address the hypothesis that expression of G4-resolving RECQ helicases declines with age concomitant with G4…
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