grant
Fusion pore structure and dynamics
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2032
NIHUS FederalResearch GrantFY2026AddressAssayBioassayBiological AssayBiophysicsCationsCell BodyCell FunctionCell Membrane LipidsCell PhysiologyCell ProcessCell membraneCellsCellular FunctionCellular PhysiologyCellular ProcessColoring AgentsCommunicationCommunication DisordersCommunication impairmentCommunicative DisordersComplexCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneDNADeoxyribonucleic AcidDyesElectron CryomicroscopyElectrophysiologyElectrophysiology (science)Eukaryotic CellEventExocytosisExtracellular SpaceFertilizationGlutamatesGoalsIntercellular SpaceInterventionKineticsL-GlutamateLipid BilayersMeasurementMeasuresMediatingMembraneMembrane FusionMembrane LipidsMental disordersMental health disordersMolecularNSF attachment protein receptorNanostructuresNerve CellsNerve UnitNervous SystemNeural CellNeural TransmissionNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurophysiology / ElectrophysiologyOpticsPlasma MembraneProcessProteinsPsychiatric DiseasePsychiatric DisorderRadialRadiusReactionRecombinantsRegulationRunningSNAP receptorSNARESamplingSecretory GranulesSecretory VesiclesStructureSubcellular ProcessSynapsesSynapticSynaptic TransmissionSynaptic VesiclesSystemViralWorkaqueousbiophysical foundationbiophysical principlesbiophysical sciencescryo-EMcryoEMcryogenic electron microscopyelectrophysiologicalfertilizationsglutamatergicinnovateinnovationinnovativeinsightlipid bilayer membranemembrane structuremental illnessnano mechanicsnano-sized structuresnano-structuresnanodisknanomechanicsneuronalneurotransmitter releasenovelopticalparticleplasmalemmapostsynapticpresynapticpsychiatric illnesspsychological disorderreconstitutereconstitutionresponsescaffoldscaffoldingsoluble N-ethylmaleimide-sensitive-factor attachment protein receptorsynapset-SNAREtarget SNARE proteinstarget membrane SNARE proteinsv-SNAREsvesicle releasevesicular SNARE proteinsvesicular releasevesicule SNARE proteins
Description preview
Project Summary/Abstract
Membrane fusion is a fundamental process in eukaryotic cells, yet the precise molecular mechanism(s) by
which proteins catalyze the merger of lipid bilayers has yet to be elucidated. We address the nanomechanics
of membrane fusion reactions by focusing on the fusion of synaptic vesicles (SV) with the presynaptic plasma…
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