grant
Fusion peptide specific B cell responses and the role of follicular T cells in accelerated antibody maturation
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 17 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2025AIDS VirusAb responseAb-mediated immunityAb-mediated protectionAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffinityAntibodiesAntibody FormationAntibody ProductionAntibody ResponseAntibody immunityAntibody protectionAntibody-mediated protectionAntigensAutologousAvidityB blood cellsB cellB cellsB-Cell ActivationB-Cell EpitopesB-CellsB-Lymphocyte EpitopesB-LymphocytesB-cellCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCell BodyCell MaturationCellsCharacteristicsChimera ProteinChimeric ProteinsClass SwitchingClass SwitchingsClinical TrialsCohort StudiesComplexConcurrent StudiesDataDevelopmentDoseEnvelope ProteinEvolutionFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFusion ProteinHIVHIV InfectionsHIV envelopeHIV envelope proteinHIV vaccineHIV/AIDS VaccinesHTLV-III InfectionsHTLV-III-LAV InfectionsHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHumoral ImmunitiesImmunityImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsIn VitroIndividualInducer CellsInducer T-LymphocytesInfectionIsotype SwitchingIsotype SwitchingsKineticsLAV-HTLV-IIILYT3LinkLymphadenopathy-Associated VirusMaintenanceMediatingModern ManOrganoidsOutcomeOutputParticipantPeptidesPersonsPlayPost-vaccination infectionProcessProtein RegionProteinsRegimenResistanceRiskRoleRunningSamplingSomatic MutationStructureSupporting CellSystemT cell responseT-CellsT-LymphocyteT8 CellsT8 LymphocytesTestingTherapeuticVaccinationVaccineeVaccinesVariantVariationViralViral DiseasesVirusVirus DiseasesVirus-HIVWorkactivated B cellsantibody biosynthesisantibody-based immunityantibody-mediated immunitybasebasesbreakthrough infectioncohortcross reactivitydesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalenv Antigensenv Gene Productsenv Polyproteinsenv Proteinflow cytophotometryhuman immunodeficiency virus vaccineimmunogenimmunogenicityimmunoglobulin biosynthesisin vivoinnovateinnovationinnovativeinsightneuralneutralizing antibodyprophylacticresistantresponsesocial rolesomatic varianttherapeutic vaccinethymus derived lymphocytetooltreatment vaccinesvaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccination studyvaccination trialvaccine developmentvaccine for the treatmentvaccine for treatmentvaccine strategyvaccine studyvaccine trialviral infectionvirus infectionvirus-induced disease
Description preview
Project 1.
Abstract: Different regions of HIV Env have been identified as targets of broadly neutralizing
Ab activity. The maturation, magnitude and breadth of such bNAb is a critical challenge for
HIV vaccine development as the evolution of these responses to broad neutralization requires
a lengthy and complex maturation process with rounds of…
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