grant
Functions and Pathogenic Mechanisms of DAGLB and the Endocannabinoid System in Parkinson's Disease
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20252-AG2-arachidonoyl-glycerol2-arachidonoyl-sn-glycerol2-arachidonoylglycerol2-arachidonyl-glycerol2-arachidonylglycerol21+ years oldAdultAdult HumanAffectAstrocytesAstrocytusAstrogliaBasal GangliaBasal NucleiBehaviorBehavioralBehavioral AssayBrainBrain Nervous SystemBrain regionCRISPRCRISPR/Cas systemCalciumClustered Regularly Interspaced Short Palindromic RepeatsCompensationDA NeuronDNA mutationDataDevelopmentDisease ProgressionDopamineDopamine neuronDysfunctionECB signalingEncephalonEndocannabinoidsEndogenous CannabinoidsEnzyme GeneEnzymesFiberFunctional disorderGenesGeneticGenetic ChangeGenetic defectGenetic mutationGoalsHortega cellHumanHydroxytyramineImmuneImmunesKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLearningLinkLocomotionMeasuresMediatingMental DepressionMesencephalonMiceMice MammalsMicrogliaMid-brainMidbrainMidbrain structureModelingModern ManMolecularMotivationMotorMovementMurineMusMutationNerve CellsNerve DegenerationNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronsNeurotransmittersNull MouseParalysis AgitansParkinsonParkinson DiseasePathogenesisPathogenicityPathway interactionsPatientsPerformancePhotometryPhysiologicPhysiologicalPhysiopathologyPrimary ParkinsonismProductionRNA SeqRNA analysisRNA sequencingRNAseqRegulationRoleRotarod AssayRotarod MethodRotarod Performance TestRotarod TestShapesSubstantia NigraSubstantia nigra structureTestingTherapeuticTimeTime PerceptionVariantVariationVentral Tegmental Areaadulthoodastrocytic gliabehavior phenotypebehavioral impairmentbehavioral phenotypingbiological adaptation to stressbody movementbrain cellcell typedepressiondevelopmentaldopaminergic neuroneCB systemearly onsetendocannabinoid signalingendocannabinoid systemendogenous cannabinoid systemgenome mutationgitter cellhuman modelimpaired behaviorimprovedinnovateinnovationinnovativeinsightinterestknock-downknockdownloss of functionloss of function mutationmesogliamicroglial cellmicrogliocytemodel of humanmotor impairmentmotor skill learningmotor symptommovement impairmentmovement limitationneural circuitneural circuitryneural degenerationneural inflammationneurocircuitryneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneuronalneuronal degenerationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynon-motor symptomnonmotor symptomnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpars compactapathophysiologypathwayperceptual motor learningperivascular glial cellpharmacologicreaction; crisissocial rolestress responsestress; reactionsynaptic circuitsynaptic circuitrytranscriptome sequencingtranscriptomic sequencingventral tegmentum
Description preview
Recently, we identified four loss-of-function mutations in the DAGLB gene in patients with familial early-onset recessive Parkinson’s disease (PD). Analysis of RNA sequencing data from dopaminergic neurons in the substantia nigra pars compacta (SNc)—a brain region critical for movement—revealed that DAGLB is the primary enzyme responsible for…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click