grant
Functional relevance of C. trachomatis trp operon polymorphism
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 19 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AllelesAllelomorphsAmino AcidsAnabolismB subtilisB. subtilisBacillus subtilisBacteriaBindingBiologicalBiologyBiosensing TechnicsBiosensing TechniquesBiosensorBlindnessBody TissuesC trachomatisC. trachomatisCD71Cell BodyCell DifferentiationCell Differentiation processCellsCephalinsChimera ProteinChimeric ProteinsChlamydiaChlamydia trachomatisCodonCodon NucleotidesCompensationConsumptionDNA mutationDataDependenceDeveloped CountriesDeveloping CountriesDeveloping NationsDevelopmentDiphosphatesDown-RegulationE coliE. coliElementsEnsureEnvironmentEpithelial CellsEquityEscherichia coliEthanolamine PhosphoglyceridesEthanolamineglycerophospholipidsEvolutionFe elementFelisFemaleFusion ProteinGene ArrangementGene OrderGene PositionGene TranscriptionGeneralized GrowthGenerationsGenesGeneticGenetic ChangeGenetic PolymorphismGenetic TranscriptionGenetic defectGenetic mutationGenomeGenus FelisGlnGlutamineGrowthIndolesIndustrialized CountriesIndustrialized NationsIntercistronic RegionIntergenic RegionsInternetInvestigationIronKynureninaseKynurenineL-GlutamineL-SerineL-TryptophanLess-Developed CountriesLess-Developed NationsLevotryptophanLinkLocationMediatingMedicalMetabolicMetabolic PathwayMiyagawanellaModelingMolecular InteractionMutationNon-Polyadenylated RNANutrientNutritionalNutritional RequirementsO-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)-ethanolamineORFsOpen Reading FramesOperonPRO1557Pathway interactionsPhosphatidylethanolaminePhosphatidylserinesPhosphoenolpyruvatePhysical condensationProcessProductionProkaryotaeProkaryotic CellsPropertyProtein Coding RegionProtein PrecursorsPyrophosphatesQ LevoglutamideQ. LevoglutamideRNARNA ExpressionRNA Gene ProductsReactionRegulationReportingResearch ResourcesResourcesRibonucleic AcidRibosomesRickettsia trachomaeRoleSerineSerine PhosphoglyceridesSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSquamous EpitheliumStarvationStratified Squamous EpitheliumStructureTF geneTFR geneTFR proteinTFR1TFRCTFRC geneTRAP ComplexTRAP MediatorTRAP/Mediator ComplexTRFRThird-World CountriesThird-World NationsThyroid Hormone Receptor-Associated Protein ComplexTissue GrowthTissuesTrans-Acting FactorsTrans-ActivatorsTransactivatorsTranscriptionTranscription RepressorTranscriptional ControlTranscriptional RegulationTranscriptional RepressorTransferrin GeneTransferrin ReceptorTransferrin Receptor 1TranslationsTryptophanTryptophan SynthaseTryptophan SynthetaseUnder-Developed CountriesUnder-Developed NationsVenereal DiseasesVenereal DisordersVenereal InfectionsWWWWorkaminoacidanthranilateantiterminationattenuationbedsoniabiologicbiological sensorbiosensingbiosynthesiscellular differentiationclinical relevanceclinically relevantcondensationcostderepressiondeveloped countrydeveloped nationdeveloped nationsdeveloping countrydeveloping nationdevelopmentaldriving forceenzyme activityerythrose 4-phosphategenetic repressorgenital tractgenome mutationgenome scalegenome-widegenomewidehuman pathogenin vivoinhibitorinterestkynurenine hydrolaselab assignmentlab experimentlaboratory activitylaboratory assignmentlaboratory exerciselaboratory experimentmetabolism measurementmetabolomicsmetabonomicsmicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramultispecies consortianutrient requirementnutritiousontogenyparticlepathogenpathwaypolymorphismpreventpreventingprogramsprokaryotepromoterpromotorreceptor recyclingreproductive tractsexually acquired infectionsocial rolestemtranslationtryptophan desmolasevision lossvisual losswebworld wide web♀
Description preview
PROJECT SUMMARY
The trp operon in several bacterial species is regulated at multiple levels that include transcription, translation,
post-translation, and enzyme activity. The recent discovery of a distinct attenuation mechanism of C. trachomatis
trp operon, which we termed “trans”-attenuation because it involved a trans-acting factor, the…
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