grant
Functional outcomes of inflammatory bowel disease associated variants
Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 18 Sept 2013Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Acetylmuramyl-Alanyl-IsoglutamineActive OxygenAutocrine SystemsAutoimmune StatusAutoimmunityAutomobile DrivingBlood monocyteBody TissuesCOT GeneCOT proteinCancer Osaka Thyroid OncogeneCancer Osaka Thyroid Oncogene ProteinCandidate Disease GeneCandidate GeneCell BodyCellsClassificationColony-forming unitsDeubiquitinating EnzymeDevelopmentDiathesisDiseaseDisease susceptibilityDisorderEST geneEST proteinEndoplasmic ReticulumEquilibriumErgastoplasmEwing Sarcoma TransformantFutureGenesGeneticGenetic DiseasesGenetic DiversityGenetic PolymorphismGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic VariationGenetic propensityHumanHuman GeneticsImmuneImmune responseImmunesIndividualInfectionInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInherited PredispositionInherited SusceptibilityIntestinalIntestinal DiseasesIntestinal DisorderIntestinesJAK-2JAK2JAK2 geneJAK2 proteinJanus kinase 2MAP Kinase Kinase Kinase 8MAP3K8MAP3K8 geneMGF proteinMGSNF proteinMacrophageMapsMarrow monocyteMediatingMicrobeMitogen-Activated Protein Kinase Kinase Kinase 8Modern ManMolecularMuramyl DipeptideMφOncogene COTOutcomeOxygen RadicalsPathogenesisPathway interactionsPatientsPattern RecognitionPattern recognition receptorPredispositionPro-OxidantsProteinsQTLQuantitative Trait LociReactive Nitrogen SpeciesReactive Oxygen SpeciesReceptor ActivationReceptor ProteinRisk-associated variantRoleSTAT1STAT1 geneSTAT3STAT3 geneSTAT4STAT4 geneSTAT5STAT5ASTAT5A geneSTAT5a Transcription FactorSTAT91Signal Transducer and Activator of Transcription 5ASingle Base PolymorphismSingle Nucleotide PolymorphismStat5 proteinStat5a proteinStat5alpha proteinSusceptibilitySystemSystematicsTL1TLR proteinTNF Ligand-Related Molecule 1TNF15TNFSF15TNFSF15 geneTPL-2TPL2TestingTissuesToll-Like Receptor Family GeneToll-like receptorsTumor Necrosis Factor Ligand Superfamily Member 15Tumor Progression Locus-2Tyrosine-Protein Kinase JAK2Ulcerated ColitisUlcerative ColitisVEGIVariantVariationVascular Endothelial Growth Inhibitoranti-microbialantimicrobialautocrinebalancebalance functionbowelcohortcytokinede-ubiquitinasede-ubiquitinating enzymedensitydevelopmentaldisease classificationdisorder classificationdrivingfunctional outcomesgain of functiongene functiongene locusgenetic conditiongenetic disordergenetic etiologygenetic locusgenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgenomic locationgenomic locushost responsehuman diseaseimmune system responseimmunoresponseimprovedin vivoinflammatory disease of the intestineinflammatory disorder of the intestineinsightinter-individual variabilityinter-individual variationintestinal autoinflammationintestine diseaseintestine disorderknock-downknockdownliability to diseasemammary gland factormammary gland-specific nuclear factormicrobialmicrobial diseasemicrobial productsmonocytenew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnosologynovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetparacrinepathwaypolymorphismreceptorresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsignal tranducer and activator of transcription 5single nucleotide variantsocial roletherapeutic targetubiquitin isopeptidaseubiquitin-specific isopeptidase
Description preview
Project Summary/Abstract
The interplay between microbial and genetic susceptibility factors is central to the development of
inflammatory bowel disease (IBD). Innate mechanisms, in particular through pattern recognition receptor
(PRR) pathways, are the initiating drivers of host responses to microbes. Of the >240 loci associated to
IBD, a number…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click