grant
Functional Networks of White Matter in Alzheimer's Disease and their Associations with Cognitive Decline
Organization NEW JERSEY INSTITUTE OF TECHNOLOGYLocation NEWARK, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD dementiaAddressAdultAdult HumanAffectAffectiveAgeAged 65 and OverAgingAlgorithmsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's diagnosisAlzheimer's disease diagnosisAlzheimers DementiaAmentiaAmericanApplications GrantsAtlasesBehaviorBrainBrain DiseasesBrain DisordersBrain MappingBrain Nervous SystemBrain regionCell Communication and SignalingCell SignalingCharacteristicsClassificationClinicalCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunicationCommunitiesCorpus CallosumCorpus CallosumsDataData SetDegenerative Neurologic DisordersDementiaDevelopmentDiagnosisDimensionsDiseaseDisease ProgressionDisorderDisturbance in cognitionDysfunctionEncephalonEncephalon DiseasesFoundationsFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsGrant ProposalsGraphHumanImpaired cognitionIndividualIntelligenceIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationKnowledgeLanguageLiquid substanceMRI biomarkerMRI markerMachine LearningMapsMeasuresMemoryMemory DeficitMemory impairmentMental disordersMental health disordersMethodologyMethodsMiningModern ManMotorNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologicalParticipantPathogenesisPathway interactionsPatientsPhenotypePhysiopathologyPrimary Senile Degenerative DementiaProcessPrognosisPropertyPsychiatric DiseasePsychiatric DisorderResearchRestSample SizeScanningSensorySeriesSignal TransductionSignal Transduction SystemsSignalingStructureSystematicsSystems IntegrationTestingThinkingWorld Health Organizationabove age 65adulthoodadvanced analyticsafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65agesbiological signal transductionbrain volumeclinical predictorscognitive dysfunctioncognitive lossconnectomedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalexecutive controlexecutive functionfMRIfield based datafield learningfield studyfield testfluidgray matterhuman old age (65+)imaging propertiesimaging studyimprovedintegrated systemliquidmachine based learningmagnetic resonance imaging biomarkermagnetic resonance imaging markermemory dysfunctionmental illnessmild cognitive disordermild cognitive impairmentneuralneural imagingneuro-imagingneurodegenerative illnessneuroimagingneurological imagingneurophysiologicalneurophysiologyneurosurgeryover 65 yearspathophysiologypathwayprimary degenerative dementiapsychiatric illnesspsychological disorderresponsesenile dementia of the Alzheimer typesubstantia albasubstantia griseasystem integrationthoughtstime intervaltime usetraitvectorwhite matter≥65 years
Description preview
Alzheimer's disease (AD) is a neurodegenerative disorder that affects a patient’s memory, language, and
executive function. AD affects one in nine (>10%) in the US aged 65 years and older. The specific pathogenesis
and the underlying neurophysiology of AD have not been fully understood. The white matter (WM) regions of the
brain, making up…
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