grant
Functional Interrogation of Type 2 Diabetes-associated Genetic Network
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 19 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AddressAdult-Onset Diabetes MellitusAllelic ImbalanceAutomobile DrivingB9 endocrine pancreasBeta CellBindingBiochemicalBiologic ModelsBiological FunctionBiological ModelsBiological ProcessBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCausalityCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessCellular injuryChromatinClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexDNA BindingDNA Binding DomainDNA Binding InteractionDNA boundDNA-Binding Protein MotifsDefectDevelopmentDiseaseDisease ProgressionDisorderDysfunctionEndocrineEndocrine PancreasEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyFunctional disorderGWA studyGWASGene ExpressionGene TranscriptionGene variantGenerationsGenesGeneticGenetic TranscriptionHealthHumanHumulin RImpairmentIn VitroIndividualInsulinInsulin CellInsulin Secreting CellIntracellular Communication and SignalingIslands of LangerhansIslet CellIslets of LangerhansKetosis-Resistant Diabetes MellitusLightLinkMapsMaturity-Onset Diabetes MellitusMeasuresMediatingModel SystemModern ManMolecularMolecular InteractionNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin ROrganoidsOutcomePancreatic IsletsPars endocrina pancreatisPhotoradiationPhysiopathologyProductionProgenitor CellsProloprimPublishingQuantitative RTPCRQuantitative Reverse Transcriptase PCRRFX1RFX3RNA ExpressionRegular InsulinRisk-associated variantRoleSchemeSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessSystemT2 DMT2DT2DMTherapeutic InterventionTissuesTranscriptionTrimethoprimTrimpexType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVariantVariationWFS1WFS1 geneWolframinadult onset diabetesallelic variantbiological signal transductioncausationcell damagecell injurycellular damagecellular differentiationdamage to cellsdevelopmentaldifferentiation protocoldisease causationdrivingepigeneticallygenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic varianthESChuman ES cellhuman ESChuman derived pluripotent stem cellhuman embryonic stem cellhuman pluripotent stem cellin vitro Modelin vivoinjury to cellsinsightinsulin secretionintervention therapyisletketosis resistant diabetesmaturity onset diabetesoverexpressoverexpressionpathophysiologyqRTPCRresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem cellssuccesstype 2 DMtype II DMtype two diabeteswhole genome association analysiswhole genome association studyβ-cellβ-cellsβCell
Description preview
Abstract. Type 2 diabetes (T2D) is a polygenetic disease marked by impaired insulin secretion in pancreatic
islet cells. Although genome-wide association studies (GWAS) have identified many T2D-associated genetic
variants/genes, understanding the molecular mechanism and cellular consequence of GWAS identified hits
remains challenging. In addition,…
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