grant
Functional Dissection of Metabolic-Sensing Proline Hydroxylation Pathways
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Sept 2017Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20252-ketoglutarate2-oxoglutarate4 HydroxyprolineBiochemicalBody TissuesCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessChemicalsChromatinDevelopmentDiseaseDisorderDissectionEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFe elementFumaratesGene ExpressionGoalsHydroxylationHydroxyprolineHypoxiaHypoxicIndividualInflammationIntracellular Communication and SignalingIronL-ProlineMalignant CellMalignant NeoplasmsMalignant TumorMediatingMetabolicMetabolic DiseasesMetabolic DisorderMetabolic Protein DegradationMiceMice MammalsMitochondriaModificationMurineMusO elementO2 elementOxygenOxygen DeficiencyOxyprolinePathway interactionsPeptidyl Prolyl HydroxylasePhysiologicPhysiologicalPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcollagen Prolyl 4-HydroxylaseProcollagen-Proline DioxygenaseProliferatingProlineProline HydroxylaseProline,2-Oxoglutarate 4-DioxygenaseProlyl 4-HydroxylaseProlyl HydroxylaseProtein ModificationProtein TurnoverProteinsProteomeProteomicsProtocollagen Prolyl HydroxylaseRegulationRegulatory PathwayRegulatory Protein DegradationResearchRoleSignal TransductionSignal Transduction SystemsSignalingSiteSubcellular ProcessSuccinatesSystemThesaurismosisTissuesalpha ketoglutaratebiological signal transductioncancer cellcancer progressiondevelopmentalepigeneticallyexperiencemalignancymetabolism disordermitochondrialneoplasm progressionneoplasm/cancerneoplastic progressionnovelpathwayprotein degradationprotein protein interactionresponsesensorsocial rolesuccesstechnology platformtechnology systemtooltranslational opportunitiestranslational potentialtumor progressionα-ketoglutarateα-oxoglutarateαKG
Description preview
Project Summary
Proline hydroxylation (Hyp) is a fundamental posttranslational modification and regulatory mechanism that are
highly responsive to the changes in cellular metabolic conditions. During tumor progression, the rapid
proliferation of cancer cells creates a hypoxic microenvironment that inhibits the hydroxyproline-mediated
degradation…
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