grant
Functional consequences of high glucose culture on adoptive T cell therapies for cancer
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026(TNF)-αAdoptive Cell TransfersAdoptive TransferAffectB16F10BackBindingBlood GlucoseBlood SugarCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCD19CD19 geneCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCachectinCancer ModelCancer TreatmentCancerModelCell BodyCell Communication and SignalingCell Culture TechniquesCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCellsClinicalCulture MediaD-GlucoseDataDextroseDorsumEnvironmentEnzyme AntagonistEnzyme GeneEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsEnzymesExposure toFormulationGene ModifiedGlucoseHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHumanHyperglycemiaIFN-GammaIFN-gIFN-γIFNGIFNγIVIS SpectrumCTIVIS imagingIVIS optical imagingIVIS spectral imagingIVIS spectrumIVIS systemImmuneImmune InterferonImmune PrecipitationImmune mediated therapyImmunesImmunologically Directed TherapyImmunoprecipitationImmunotherapyIn VitroInterferon GammaInterferon Type IIIntracellular Communication and SignalingL-SerineL-ThreonineLinkMHC ReceptorMacrophage-Derived TNFMajor Histocompatibility Complex ReceptorMalignant Hematologic NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMetabolicMetabolic GlycosylationMetabolic dysfunctionMethodsMiceMice MammalsModern ManMolecular InteractionMonocyte-Derived TNFMurineMusNutrientO-GlcNAc Transferase geneO-GlcNAc transferaseOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhasePhosphorylationPhosphorylation SitePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreparationProceduresProductionProliferatingProtein GlycosylationProtein ModificationProtein PhosphorylationProteinsProteomeProteomicsReceptor ProteinRelapseRoleSerineSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSolid NeoplasmSolid TumorT cell based immune therapyT cell based therapeuticsT cell based therapyT cell differentiationT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cells for CART cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyT8 CellsT8 LymphocytesTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTeff cellTestingThreonineTimeTranslatingTumor BurdenTumor ImmunityTumor LoadTumor Necrosis FactorTumor Necrosis Factor-alphaadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyadoptive cell therapyadoptive cellular therapyanti-cancer therapyanti-tumor immunityantitumor immunitybiological signal transductioncancer immunitycancer microenvironmentcancer therapycancer-directed therapycell culturecell culturescell sortingchimeric antigen T cell receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellscytokineeffector T cellextracellularflexibilityflexiblegene modificationgenetically modifiedglycosylationgrowth mediahuman modelhyperglycemicimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprintin vivoin vivo imaging systeminsightlFN-Gammamedia consumptionmedia usemodel of humanpatient oriented outcomespatient responsepatient specific responsepatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespreparationsreceptorresponseresponsive patientretroviral transductionsocial rolesuccesstherapeutic T-cell platformthymus derived lymphocytetranslational modeltumortumor growthtumor microenvironment
Description preview
PROJECT SUMMARY/ABSTRACT
Adoptive cell therapy (ACT) is a form of immunotherapy in which T cells are isolated from a patient, genetically
modified, expanded in vitro and then transferred back to the patient to initiate antitumor immunity. Chimeric
antigen receptor T cells (CAR-T) is a form of ACT where the T cells are modified to contain a tumor…
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