grant
Functional and mechanistic studies of human-specific long noncoding RNAs using a humanized mouse model
Organization NATIONAL HEART, LUNG, AND BLOOD INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressBasal Transcription FactorBasal transcription factor genesBody TissuesExposure toFoundationsFunctional RNAFutureGeneral Transcription Factor GeneGeneral Transcription FactorsHumanHuman GenomeIntermediary MetabolismLiverMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMurineMusNoncoding RNANontranslated RNAPathway interactionsPhysiologicPhysiologicalRNA SeqRNA sequencingRNAseqRegulationResearch ResourcesResourcesRoleStimulusTissuesTranscriptTranscription Factor Proto-OncogeneTranscription factor genesUntranslated RNAfeedingglobal gene expressionglobal transcription profilehepatic body systemhepatic organ systemhuman whole genomehumanized micehumanized mousemRNA Expressionmouse modelmurine modelnano porenanoporenoncodingnovelpathwaysocial roletranscription factortranscriptometranscriptome sequencingtranscriptomic sequencing
Description preview
We previously addressed the challenge of incomplete human liver lncRNA annotation by combining an isogenic humanized mouse model with Nanopore direct RNA sequencing. This approach enabled us to generate a de novo transcript-level annotation of human liver lncRNAs under diverse metabolic conditions, uncovering numerous novel transcripts and…
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