grant
Functional anatomy, physiology and behavioral responses mediated by mu opioid receptor signaling on medial thalamic neurons.
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 May 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026Absence of pain sensationAbsence of sensibility to painAcuteAffectAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnatomic SitesAnatomic structuresAnatomyAnodynesAnteriorAntinociceptive AgentsAntinociceptive DrugsAttenuatedAxon TerminalsBehaviorBehavioralBrainBrain Nervous SystemBrain regionCell BodyCellsChronicCorpus StriatumCorpus striatum structureDREADDsDataDissociationDoseDrugsElectrophysiologyElectrophysiology (science)EncephalonFeels no painGeneticGlutamatesGlyceryl TrinitrateGoalsHyperactivityHyperalgesiaHyperalgesic SensationsImageImmunofluorescenceImmunofluorescence ImmunologicIndividualInfumorphInjuryKadianKnock-outKnockoutKnowledgeL-GlutamateLeadLearningLinkLocationLoxP-flanked alleleMS ContinMSirMapsMechanicsMedialMediatingMedicationMiceMice MammalsMidline Nuclear GroupMidline Nuclei of ThalamusMidline Thalamic NucleiMorphiaMorphineMotivationMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural TransmissionNeurocyteNeuronal DifferentiationNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNitroglycerinNo sensitivity to painOpiate AddictionOpiate DependenceOpiate ReceptorsOpiate agonistOpiate receptor agonistOpiatesOpioidOpioid ReceptorOpioid agonistOpioid receptor agonistOramorphOramorph SROutcomePainPain ControlPain TherapyPain managementPainfulPatternPb elementPeriventricular Nuclei of ThalamusPersonsPharmaceutical PreparationsPhysiologyPopulationPresynaptic Nerve EndingsPresynaptic TerminalsPropertyReceptor ActivationReceptor SignalingRelapseRewardsRoleRoxanolSliceSpecificityStatex SRStimulusStriate BodyStriatumSynaptic BoutonsSynaptic TerminalsSynaptic TransmissionTestingThalamic structureThalamusTransmissionVirusWithdrawalWorkabuse liabilityabuse potentialanalgesiaattenuateattenuatesaxon signalingaxon-glial signalingaxonal signalingbehavior responsebehavioral pharmacologybehavioral responsecell typechronic paincingulate cortexdesigner receptors exclusively activated by designer drugsdrug/agentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfloxedfloxed allelegene manipulationgenetic manipulationgenetically manipulategenetically perturbglia signalingglial signalingglutamatergicheavy metal Pbheavy metal leadhyperalgiaimaginginjuriesinnervationintravenous opiateintravenous opioidlicit opioidmechanicmechanicalmu opioid receptorsnerve signalingnerve supplyneuralneural circuitneural circuitryneural signalingneurocircuitryneuronalneuronal signalingneurotransmissionopiate consumptionopiate drug useopiate injectionopiate intakeopiate medicationopiate useopiate withdrawalopioid addictionopioid consumptionopioid dependenceopioid dependentopioid detoxopioid detoxificationopioid drug useopioid injectionopioid injectoropioid intakeopioid medicationopioid useopioid withdrawaloptogeneticspain interventionpain killerpain medicationpain modelpain perceptionpain processingpain reductionpain reliefpain relieverpain sensitivitypain treatmentpainkillerpharmacobehavioralprescribed opiateprescribed opioidprescription opiateprescription opioidpreventpreventingreceptor expressionreduce painrelieve painresponsereward processingsexsocial rolestriatalsynaptic circuitsynaptic circuitrythalamictransmission processtrinitrate 1,2,3-Propanetriolμ opioid receptorsμ-ORμOR
Description preview
Project Summary/ Abstract
Opioids like morphine are the most effective pain relieving drugs available but their rewarding properties lead
to misuse. The rewarding and analgesic properties of opioids are mediated by activation of mu opioid receptors
(MOR). Hyperalgesia is an exaggerated pain perception in response to a stimulus that is normally…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click