grant
Function of RecQ helicases in genome stability
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AgingBiochemicalBiochemical ProcessCancerousCancersCell BodyCellsCharacteristicsCodeCoding SystemDNADNA DamageDNA Damage RepairDNA Double Strand BreakDNA Helicase, RecQ-Like, Type 1DNA HelicasesDNA InjuryDNA RepairDNA StructureDNA Unwinding ProteinsDNA mutationDNA unwinding enzymeDeoxyribonucleic AcidDiseaseDisorderDouble Strand Break RepairEnzyme GeneEnzymesGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityHumanLifeLightMalignant NeoplasmsMalignant TumorMendelian diseaseMendelian disorderMendelian genetic disorderMetabolic PathwayModern ManMolecularMutateMutationNHEJNon-Homologous End JoiningNon-homologous DNA End JoiningNonhomologous DNA End JoiningNonhomologous End JoiningPathway interactionsPatientsPhotoradiationPlayPremature AgingPremature aging syndromeProcessProteinsRECQ Protein-LikeRECQ4RECQ5RECQLRECQL geneRECQL1RECQL4RECQL4 geneRECQL5RECQL5 geneResearchRoleSyndromeTimeUnscheduled DNA Synthesisage associatedage correlatedage dependentage linkedage relatedage specificaging associatedaging preventionaging relatedanti aginganti geronicantiaginggenome mutationhelicasehomologous recombinationmalignancymembermonogenic diseasemonogenic disorderneoplasm/cancerpathwayprevent age relatedprevent agingprotein functionsingle-gene diseasesingle-gene disordersocial rolesuppress aging
Description preview
DNA damage accumulates during life and is thought to contribute to aging and genomic instability. Therefore, defining those proteins and pathways that maintain genomic stability is critical in preventing aging and age-related degeneration. This project aims to understand what roles human RecQ proteins play in DNA repair and genome stability.…
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