grant
Function of maternal mRNA during zebrafishembryogenesis
Organization STOWERS INSTITUTE FOR MEDICAL RESEARCHLocation KANSAS CITY, UNITED STATESPosted 13 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AddressAreaBrachydanio rerioCRISPRCRISPR/Cas systemCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessClustered Regularly Interspaced Short Palindromic RepeatsCodonCodon NucleotidesDanio rerioDevelopmentDevelopmental BiologyEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentFecundabilityFecundityFertilityGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenomeGoalsIndividualKnowledgeMasksMaternal Messenger RNAMaternal mRNAMediatingMessenger RNAMolecularMolecular Dynamics SimulationNon-Polyadenylated RNAORFsOpen Reading FramesOrganismPhenotypeProcessProtein Coding RegionProteinsProteomicsRNARNA DecayRNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqRegenerative MedicineRegulationRegulatory ElementRegulatory PathwayReproductive HealthResearchRibo-seqRibonucleic AcidRoleSightSubcellular ProcessSystemTechniquesTechnologyTherapeuticTranscriptTranscriptionTranslatingTranslational RegulationTranslationsUTRsUntranslated RegionsVisionWorkZebra DanioZebra FishZebrafishdevelopmentalgene functiongenetic approachgenetic strategyinnovateinnovationinnovativeinsightknock-downknockdownliving systemmRNAmRNA StabilitymRNA Translationmolecular dynamicsmultiomicsmultiple omicsnovelpanomicsposttranscriptionalprogramsribosome footprint profilingribosome profilingsocial rolespatial and temporalspatial temporalspatiotemporaltooltranscriptome sequencingtranscriptomic sequencingtranslationvisual function
Description preview
Project Summary
Our research focuses on unraveling the fundamental processes of early vertebrate embryogenesis, particularly
the dynamic molecular mechanisms that regulate maternal and zygotic RNAs during the maternal-to-zygotic
transition (MZT). This crucial period involves the degradation of maternal RNAs and activation of the zygotic
genome,…
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