grant
Function and Therapeutic Implications of NRG3 in Breast Cancer Brain Metastasis
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAccelerationAutocrine SystemsAutomobile DrivingBar CodesBi-specific antibodiesBifunctional AntibodiesBiological MarkersBispecific AntibodiesBone MetastasisBone cancer metastaticBony metastasisBrainBrain MetastasisBrain Nervous SystemBreast CancerBreast Cancer CellBreast Cancer ModelBreast Cancer PatientBreast Cancer TreatmentBreast Tumor PatientBreast biopsyBreast tumor modelCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsClassificationClinicalCoupledDNA Synthesis FactorDepositDepositionDetectionDiagnosisDisease ProgressionDistantDistant CancerDistant MetastasisECMENX-1EZH1EZH2EZH2 geneEcologic SystemsEcological SystemsEcosystemEncephalonEndothelial Cell Growth FactorEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toExtracellular MatrixFDA approvedFGFFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Fibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorFluorescenceFoundationsGEM modelGEMM modelGeneticGenetically Engineered MouseGenomicsGoalsHR positiveHeterodimerizationIRESImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn VitroIncidenceInternal Ribosome Entry SegmentInternal Ribosome Entry SiteIntracellular Communication and SignalingKMT6KMT6AKnock-outKnockoutKnowledgeLabelLesionLigandsLightLoxP-flanked alleleMICMETMalignant Breast NeoplasmMalignant CellMapsMechanistic Target of RapamycinMediatingMetastasisMetastasis to boneMetastasizeMetastatic Cancer to the BoneMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the BoneMetastatic Neoplasm to the BrainMetastatic TumorMetastatic Tumor to the BoneMetastatic Tumor to the BrainMetastatic malignant neoplasm to boneMetastatic malignant neoplasm to brainMiceMice MammalsMicrometastasisMicrometsMicroscopyModelingMurineMusNRG3NRG3 geneNeoplasm Circulating CellsNeoplasm MetastasisNerve CellsNerve UnitNeural CellNeuregulin 3NeurocyteNeuronsOrganOsseous metastasisPatientsPhenotypePhotoradiationPre-Clinical ModelPreclinical ModelsPrimary NeoplasmPrimary TumorProcessRAFT1RelapseRibosome Entry SiteRoleSecondary NeoplasmSecondary TumorSecondary cancer of boneSecondary malignancy of boneSecondary malignant neoplasm of boneSignal TransductionSignal Transduction SystemsSignalingSiteSkeletal metastasisSynapsinsSystematicsTNBCTestingTherapeuticVisceralVisceral metastasisadvanced breast canceradvanced stage breast cancerautocrinebarcodebio-markersbiologic markerbiological signal transductionbiomarkerbonebone cellbone neoplasm secondarybrain cellbrain micrometastasisbrain remodelingbreast cancer progressionbreast tumor cellbsAbc mycc-myc Genescancer cellcancer metastasiscancer microenvironmentcirculating neoplastic cellcirculating tumor cellcmycdrivingepigeneticallyfloxedfloxed allelegenetically engineered mouse modelgenetically engineered murine modelhormone receptor +hormone receptor-positiveindividuals with breast cancerinhibitormTORmalignant breast tumormammalian target of rapamycinmammary cancer modelmammary tumor modelmetastasis preventionneuronalneutralizing antibodynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachosteogenicpatients with breast cancerperson with breast cancerpharmacologicpre-clinicalpreclinicalshRNAshort hairpin RNAsingle cell analysissmall hairpin RNAsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssurvival outcomethree dimensionaltriple-negative breast cancertriple-negative invasive breast carcinomatumortumor cell metastasistumor microenvironmentv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog
Description preview
ABSTRACT
The goal of this project is to uncover the mechanisms driving brain metastasis occurrence in breast
cancer models that are clinically less associated with brain metastasis at diagnosis.
Metastasis stands as the utmost obstacle to Breast Cancer treatment. While both genomic and
epigenetic increase in complexity during metastasis, bone has…
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