grant
Full Project 3 – Pancreatic ADM
Organization FLORIDA AGRICULTURAL AND MECHANICAL UNIVLocation TALLAHASSEE, UNITED STATESPosted 19 Sept 2018Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAcinar CellAciner CellsAcinus organ componentAddressBody TissuesCaliforniaCancer cell lineCancersCaringCatchment AreaCell BodyCell LineCell ReprogrammingCell-Extracellular MatrixCellLineCellsCharacteristicsChronicCo-cultureCocultivationCocultureCoculture TechniquesCold-Insoluble GlobulinsCollagenConditioned Culture MediaConditioned MediumDataDevelopmentDiseaseDisorderDrugsDuctDuct (organ) structureDuctal CellDuctal Epithelial CellECMEarly DiagnosisEarly treatmentEducationEducational aspectsEsteroproteasesEventExperimental ModelsExtracellular MatrixFN1Fibronectin 1FibronectinsFloridaFundingGene ExpressionGenesGenetic MarkersGoalsHDAC AgentHDAC inhibitorHealthHeterogeneityHistone Deacetylase InhibitorHistone deacetylase inhibitionHumanImmuneImmunesImmunofluorescenceImmunofluorescence ImmunologicIn SituIncidenceIndividualInflammationInflammatoryLETS ProteinsLarge External Transformation-Sensitive ProteinLesionLinkMacrophageMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMedicationMetabolic stressMetaplasiaMetaplastic ChangeMethodsMicroscopicModern ManMolecularMφNormal RangeNormal ValuesOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOutcomeOxidative StressPDA modelPDAC ModelPancreasPancreas CancerPancreas Ductal AdenocarcinomaPancreaticPancreatic CancerPancreatic Ductal AdenocarcinomaPathway interactionsPatient Self-ReportPatientsPenetrationPeptidasesPeptide HydrolasesPersonsPharmaceutical PreparationsPhenotypePilot ProjectsPopulationProcessPrognosisProtease GeneProteasesProteinasesProteolytic EnzymesPublishingRNA SeqRNA sequencingRNAseqRoleSamplingSelf-ReportStaining methodStainsStrains Cell LinesStromal CellsSystemTSA antibioitcTissue DonorsTissuesTrichostatin Aacinusalpha 2-Surface Binding Glycoproteinanti-cancer researchbiophysical approachesbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical methodologybiophysical methodsbiophysical parametersbiophysical propertiesbiophysical techniquescancer microenvironmentcancer researchcellular reprogrammingchronic pancreatitisco-morbidco-morbiditycombatcomorbiditycultured cell linedevelopmentaldrug/agentearly detectionearly therapyeffective therapyeffective treatmentgene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkerimprovedinhibitorirritationmalignancymouse modelmurine modelneoplasm/cancernovelpancreas developmentpancreatic ductal adenocarcinoma modelpancreatic malignancypancreatic metaplasiapancreatic stellate cellpathwaypharmacologicpilot studypreventpreventingrecurrent pancreatitisresponse to therapyresponse to treatmentscATAC sequencingscATAC-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolestellate celltherapeutic responsetherapeutic targettherapy responsethree dimensionaltranscriptome sequencingtranscriptomic sequencingtreatment responsetreatment responsivenesstricostatin Atumor microenvironment
Description preview
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancers with poor prognosis and rising incidence. To combat this deadly disease, we should direct our efforts toward preventing PDAC or halting the progression of precursor lesions to invasive disease in parallel to developing novel treatments. One of the earliest known…
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