grant
From genotype to phenotype in a GWAS locus: the role of REST in atherosclerosis
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20267B4 Antigen7B4 proteinASCVDAdeno-Associated VirusesAdvisory CommitteesAffectAllelesAllelomorphsAortaArteriesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAwardBasal Transcription FactorBasal transcription factor genesBayesian MethodBayesian MethodologyBayesian Statistical MethodBayesian approachesBayesian classification methodBayesian classification procedureBayesian posterior distributionBinding SitesBiologyBlood VesselsBody TissuesCALL proteinCD144 AntigenCD31CRE RecombinaseCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCamL1 Gene ProductCardiovascular DiseasesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCas nuclease technologyCause of DeathCell Surface Glycoprotein L1Cellular AssayCessation of lifeChIP SequencingChIP assayChIP-seqChIPseqChromosome 4ClinicalClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo(beta)-cyano-7''-(2-methyl)adeninylcobamideCombining SiteCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary DiseaseCoronary heart diseaseDNADataData SetDeathDeoxyribonucleic AcidDependoparvovirusDependovirusDevelopmentDiseaseDisorderDistalDistantENOSEndothelial CellsEndothelial Nitric Oxide SynthaseEndotheliumEnhancersEnterobacteria phage P1 Cre recombinaseEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toF11 GlycoproteinFunctional RNAFundingFutureGWA studyGWASGene InactivationGene SilencingGene TargetingGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic RiskGenomicsGenotypeHeritabilityHigh Fat DietHumanHuman GeneticsImmunofluorescenceImmunofluorescence ImmunologicIn VitroIndividualInjectionsInvestigationInvestigatorsK-AwardsK-Series Research Career ProgramsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceL1 Cell Adhesion MoleculeL1CAMLaboratoriesLoxP-flanked alleleMMPsMatrix MetalloproteinasesMediatingMentorsMesenchymalMethodsMiceMice MammalsModern ManMultiomic DataMurineMusNGF-Inducible GlycoproteinNILE GlycoproteinNILE ProteinNOS3NOS3 geneNerve Growth Factor-Inducible Large External GlycoproteinNetwork AnalysisNeural Adhesion Molecule L1Neural Cell Adhesion Molecule L1Nitric Oxide Synthase 3Noncoding RNANontranslated RNANull MousePECAM1PECAM1 genePathway AnalysisPathway interactionsPermeabilityPhenotypePhysiciansPopulationPostdocPostdoctoral FellowProteinsPublic HealthPublishingRNA SeqRNA sequencingRNAseqReactive SiteResearchResearch AssociateResearch Career ProgramResearch PersonnelResearchersRestRisk-associated variantRoleSOX18SOX18 geneSRY-Box 18ScientistShort interfering RNASiteSmall Interfering RNATamoxifenTask ForcesTestingTimeTissuesTranscription Factor Proto-OncogeneTranscription factor genesTranslatingType III nitric oxide synthaseUnited StatesUntranslated RNAUpstream Stimulatory FactorUpstream Transcription FactorVE-CadherinVariantVariationVascular Endothelial CadherinVascular Endothelial Cadherin 1Vascular Endothelial CellVascular EndotheliumWomanWorkadeno associated virus groupadvisory teamallelic variantangiogenesisatheromatosisatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic vascular diseasebacteriophage P1 recombinase Crecadherin 5cardiovascular disease riskcardiovascular disordercardiovascular disorder riskcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell assaychromatin immunoprecipitationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcoronary arterial diseasecoronary disorderdata integrationdesigndesigningdevelopmentaldisease riskdisorder riskeffective therapyeffective treatmentepigeneticallyexperimentexperimental researchexperimental studyexperimentsfactor Afloxedfloxed allelegene locusgenetic analysisgenetic approachgenetic locusgenetic strategygenetic variantgenome editinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic editinggenomic locationgenomic locusgenomic variantglobal gene expressionglobal transcription profilehelix-loop-helix activator USFhuman diseasehuman progenitorhuman progenitor cell derivedhuman stem cell-derivedhuman stem cellsin vivoinduced Creinducible Creinsightmenmigrationmouse modelmultidisciplinarymultiple omic datamurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnoncodingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpathwaypost-docpost-doctoralpost-doctoral traineeprogenitor cell differentiationprogenitor differentiationprogramsresearch associatesresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsiRNAsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqskillssocial rolestem and progenitor differentiationstem cell differentiationsuccesstranscription factortranscription factor MLTFtranscription factor USFtranscriptional silencingtranscriptometranscriptome sequencingtranscriptomic sequencingvascularwhole genome association analysiswhole genome association study
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Project Summary
This K08 mentored clinical scientist research career development award is a five-year program designed to
facilitate Dr. Marios Arvanitis’ (PI) development into an independent physician-investigator in vascular genetics.
Atherosclerotic cardiovascular disease (ASCVD) is a major public health burden that accounts for over
600,000…
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