grant
From bench to bednet: Developing novel mitochondrial inhibitors for killing Plasmodium in the malaria mosquito
Organization HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTHLocation BOSTON, UNITED STATESPosted 18 Dec 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2025AfricaAfrica South of the SaharaAnophelesAnopheles GenusAnopheles gambiaeAnophelinesAnti-malarialsAntiparasitic AgentsAntiparasitic DrugsAntiparasiticsAreaArtemisininsAssayAtovoquoneBedsBindingBioassayBiological AssayBiteBody TissuesCoenzyme QCoenzyme Q-Cytochrome-c ReductaseCoenzyme QH2-Cytochrome-c ReductaseCollaborationsCombined Modality TherapyComplex IIICulicidaeCytochrome b-c2 OxidoreductaseCytochrome bc1Cytochrome bc1 ComplexDataDevelopmentDihydroubiquinone-Cytochrome-c ReductaseDiseaseDisorderDrug KineticsDrug PrecursorsElectron TransportElectron Transport Complex IIIEpidemiologyEthene HomopolymersEthylene HomopolymersEthylene PolymersExhibitsExposure toFemaleFiberFoundationsFutureGenerationsGoalsHumanIn VitroInfectionInsecticide ResistanceInsecticidesInterventionKetoquinolinesLegMalariaMalaria preventionMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMedicinal ChemistryMepronMethodsMitochondriaModern ManMolecular InteractionMorbidityMorbidity - disease rateMosquito ControlMosquitoesMultienzyme ComplexesMultimodal TherapyMultimodal TreatmentOutcomeOxoquinolinesP falciparumP. falciparumP.falciparumPaludismParasite resistanceParasitesParasiticidesPerformancePharmaceutic ChemistryPharmaceutical ChemistryPharmacokineticsPlasmodiumPlasmodium InfectionsPlasmodium falciparumPolyestersPolyethylenesPolymersPolythenePopulationPro-DrugsProdrugsQH(2)-Cytochrome-c ReductaseQH(2)-Ferricytochrome-c OxidoreductaseQuinolinonesQuinolonesResidualResidual stateResistanceSiblingsSideSiteSolidSpinal ColumnSpineStressStructureStructure-Activity RelationshipSub-Saharan AfricaSubsaharan AfricaSurfaceSystemTestingTextilesTherapeuticTimeTissuesTransmissionUbihydroquinone-Cytochrome-c ReductaseUbiquinol-Cytochrome-c ReductaseUbiquinol-ferricytochrome-c oxidoreductaseUbiquinoneUbiquinone-Cytochrome b-c2 OxidoreductaseVertebral columnWellvoneabsorptionanti-malarial agentsanti-malarial drugsarteannuinartemisinineatovaquonebackbonebasebaseschemical structure functioncombination therapycombined modality treatmentcombined treatmentcompound optimizationcomputer based predictiondesigndesigningdevelopmentalefficacy studyelectron transferenzyme complexepidemiologicepidemiologicalepidemiological modelexperimentexperimental researchexperimental studyexperimentsfabricformulation optimizationin vivoinhibitorinnovateinnovationinnovativeinsecticide resistantmalaria infectionmalaria mosquitomalaria transmissionmalaria-infectedmalarial infectionmitochondrialmortalitymulti-modal therapymulti-modal treatmentmutantnext generationnoveloxidationparasite resistantpolymerpolymericpredictive modelingpreventprevent malariapreventingproduct developmentprototypepyrethroidqinghaosuquing hau sauquinghaosuresistance in parasiteresistance to Parasiteresistantresistant parasiteresistant to Parasitestructure function relationshiptooltraittransmission blockingtransmission processuptakevectorvector control♀
Description preview
Project Summary
Malaria transmission occurs through the bite of Plasmodium-infected mosquitoes of the genus Anopheles, and
in much of sub-Saharan Africa, transmission of the deadliest Plasmodium falciparum parasites is mediated by
the sibling mosquito species Anopheles gambiae and An. coluzzii. The best method available to prevent malaria…
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