grant
From Atoms to Organoids: Understanding the Conformational Landscape and Regulation of Small GTPases
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 24 Mar 2026Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY2026AddressAffectAffinityAmino AcidsAssayAttentionAutomobile DrivingBindingBinding ProteinsBioassayBiochemicalBiologicalBiological AssayCancersCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell NucleusCell SignalingCellsCellular MigrationCellular MotilityCharacteristicsCommunitiesComplexCoupledCrystallographiesCrystallographyCytosolDNA mutationDataDetectionDevelopmentDiseaseDisorderDissociationDrug DesignDrug InteractionsDrug TargetingDysfunctionEnvironmentFamilyFunctional disorderFutureGAP ProteinsGDI ProteinsGDIsGDP Dissociation FactorGDP Dissociation InhibitorsGDP Dissociation StimulatorsGDP Exchange FactorsGDP-GTP Exchange ProteinGDP-GTP Reversing FactorsGTPGTP BindingGTP GDP exchange factorGTP PhosphohydrolasesGTP boundGTPase-Activating ProteinsGTPasesGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric NeoplasmsGastric Pylorus CancerGastric TumorGene ExpressionGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGerminoblastic SarcomaGerminoblastomaGluesGoalsGrowthGuanineGuanine Nucleotide Dissociation InhibitorsGuanine Nucleotide Exchange FactorsGuanine Nucleotide Exchange ProteinGuanine Nucleotide Releasing FactorsGuanosine TriphosphateGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesGuanyl-Nucleotide Exchange FactorGuanyl-Nucleotide Releasing FactorHydrolysisIn VitroIntracellular Communication and SignalingKnowledgeLabelLigand BindingLigand Binding ProteinLigand Binding Protein GeneLigandsLinkLymphomaMalignant CellMalignant Gastric NeoplasmMalignant Gastric TumorMalignant LymphomaMalignant NeoplasmsMalignant TumorMeasurementMeasuresMediatingMethodologyMethodsMissionModelingMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMotionMutationNatureNuclear Magnetic ResonanceNucleotidesNucleusOncogenicOpticsOrganoidsPancreas NeoplasmsPancreas TumorPancreatic TumorPathologicPatientsPersonsPhasePhenotypePhysiologicPhysiologicalPhysiopathologyPositionPositioning AttributeProcessProliferatingPropertyProtein BindingProtein DynamicsProteinsRegulationRegulatory ProteinResearchResolutionReticulolymphosarcomaRhoGDIRoleShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionSmall G-ProteinsSmall GTPasesStomach CancerStomach NeoplasmsStomach TumorStructureStructure-Activity RelationshipTechniquesTimeTissue GrowthTumor CellUnited StatesVariantVariationWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyaminoacidanalogbiologicbiological signal transductionbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbound proteincancer cellcancer cell metabolismcancer metabolismcell motilitycell typechemical structure functionconformationconformationalconformational stateconformationallyconformationsdesigndesigningdevelopmentaldrivingdrug developmententire genomeexchange factorexperimentexperimental researchexperimental studyexperimentsfull genomegain of functiongain of function mutationgastric malignancygenetic regulatory proteingenome mutationgenome sequencingguanosinetriphosphataseguanosinetriphosphatase activating proteinhigh definitionhigh-resolutionimprovedinhibitorinsightleukemiamalignancymalignant stomach neoplasmmalignant stomach tumormembermutantneoplasm/cancerneoplastic cellnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetontogenyopticalpancreatic cancer cellspancreatic neoplasiapancreatic neoplasmpancreatic tumor cellspathophysiologypreventpreventingprogramsprotein protein interactionregulatory gene productresolutionsrhorho G-Proteinsrho GDIrho GTP-Binding Proteinsrho GTPasesrho Protein P21rho Small GTP-Binding ProteinsrhoB p20 GDIscreeningscreeningssocial rolestomach fundus cancerstomach pylorus cancerstructural biologystructure function relationshipsuccesstime usetooltumortumor cell metabolismtumor metabolismwhole genome
Description preview
Project Summary/Abstract
In the United States alone, over 250,000 people suffer from Small GTPase (smG) dysfunction
linked to cancer, and this number scales to 3.4 million people worldwide. The smG proteins
interconvert between the GDP-bound inactive form and the GTP-bound active form, where the
active forms bind to effector proteins to trigger…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click