grant
Foxp3 isoform expression and regulation of autoantibody production
Organization BENAROYA RESEARCH INST AT VIRGINIA MASONLocation SEATTLE, UNITED STATESPosted 19 Nov 2024Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY2026Ab responseAgeAllergyAlternate SplicingAlternative RNA SplicingAlternative SplicingAmino Acid SequenceAnimal ModelAnimal Models and Related StudiesAnti-SmithAntibodiesAntibody FormationAntibody ProductionAntinuclear AntibodiesAntinuclear FactorsAsthmaAutoantibodiesAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityAutoregulationBlood SerumBone MarrowBone Marrow Reticuloendothelial SystemBronchial AsthmaCD152CD152 AntigenCD152 GeneCD25CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCTLA 4CTLA-4 GeneCTLA4CTLA4 geneCTLA4-TMCell BodyCellsChimeraChimera organismCodeCoding SystemComplexCytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Cytotoxic T-Lymphocyte-Associated Protein 4Cytotoxic T-Lymphocyte-Associated Serine Esterase-4DNADNA mutationDeoxyribonucleic AcidDepositDepositionDevelopmentDiseaseDisorderDysfunctionEnlarged SpleenEnvironmental FactorEnvironmental Risk FactorExonsExposure toFOXP3FOXP3 geneFlareForkhead Box P3Functional disorderGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene OrganizationGene StructureGene Structure/OrganizationGenesGeneticGenetic ChangeGenetic defectGenetic mutationGerminal CenterHomeostasisHumanIL2RIL2RAIL2RA geneIPEXIgEIgG autoantibodiesImmuneImmune responseImmune systemImmunesImmunodysregulation polyendocrinopathy enteropathy X-linked syndromeImmunoglobulin EImmunoglobulin G autoantibodiesImmunomodulationIn VitroInfiltrationInflammationInflammatory ResponseIsoformsJM2KidneyKidney Urinary SystemLengthLightLungLung Respiratory SystemLupus Erythematosus DisseminatusMapsMediatingMiceMice MammalsMixed Connective Tissue DiseaseModelingModern ManMouse StrainsMurineMusMutationNephritisNuclearPBMCPathway interactionsPatientsPeripheral Blood Mononuclear CellPhenotypePhotoradiationPhysiological HomeostasisPhysiopathologyPlayPredispositionPrimary Protein StructureProductionProtein IsoformsRNA SplicingRegistriesRegulationRegulatory T-LymphocyteReportingRodentRodentiaRodents MammalsRoleSCURFINSLESamplingSelf ToleranceSerumSharp SyndromeSkinSplenomegalySplicingStructure of germinal center of lymph nodeSusceptibilitySyndromeSystemSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT4 CellsT4 LymphocytesTCGFRTestingTherapeutic InterventionTranscript Expression AnalysesTranscript Expression AnalysisTregUVBUVB radiationUltraviolet BUltraviolet B Radiationagesanalyze gene expressionanti-DNA autoantibodyanti-Smanti-dsDNA antibodiesanti-dsDNA antibodyanti-dsDNA autoantibodyantiDNA autoantibodyantibody biosynthesisantinuclear autoantibodyautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodychimerascohortcytotoxic T-lymphocyte antigen 4depositorydevelopmentaldisseminated lupus erythematosusenvironmental riskgene expression analysisgene expression assaygenes structuregenome mutationhost responseimmune modulationimmune regulationimmune system responseimmunoglobulin biosynthesisimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinsightintervention therapyirradiationlife spanlifespanlupus-likemodel of animalmouse modelmurine modelnovelpathophysiologypathwayprotein sequenceregulatory T-cellsrenalrepositoryresponseself reactive antibodysocial rolesystemic autoimmune diseasesystemic autoimmune disordersystemic autoimmunitysystemic lupus erythematosistranscriptional profilingultra violet B radiation
Description preview
PROJECT SUMMARY
Systemic Lupus Erythematosus (SLE) is a multi-systemic autoimmune disease that arises from a
combination of genetic factors, dysregulated immune responses and environmental triggers. SLE-like
phenotypes, including elevated anti-nuclear IgG autoantibody titers, kidney nephritis, splenomegaly and reduced
survival have been reported…
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