grant
Foundational Biology of Glaucoma GWAS Loci
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Mar 2024Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202617q21AD dementiaAPP geneAffectAgeAllelesAllelomorphsAlzheimer Disease 1 ProteinAlzheimer Disease Protease Nexin-IIAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's Disease Amyloid ProteinAlzheimer's amyloidAlzheimers DementiaAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta A4 Precursor ProteinAmyloid Beta A4 Protein PrecursorAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid of Aging and Alzheimer Disease ProteinAmyloid βAmyloid β A4 Protein PrecursorAmyloid β-PeptideAmyloid β-ProteinAssayAxonAβBinding ProteinsBioassayBiologicalBiological AssayBiologyBiteBlindnessBody TissuesBrainBrain Nervous SystemCandidate Disease GeneCandidate GeneCaringCell BodyCell SurvivalCell ViabilityCellsCerebralvascular Amyloid PeptideChromosomesCodeCoding SystemCompensated GlaucomaCompensative GlaucomaComplexCranial Nerve IIDNADNA mutationDataDegenerative Neurologic DisordersDeoxyribonucleic AcidDevelopmentDiseaseDisorderDysfunctionELISAEncephalonEnhancersEnzyme-Linked Immunosorbent AssayEthnic OriginEthnicityExonsEyeEyeballFamilyFamily Medical HistoryFamily Medical History EpidemiologyFamily history ofFunctional disorderGWA studyGWASGangliaGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGeneticGenetic ChangeGenetic RiskGenetic TranscriptionGenetic defectGenetic mutationGenetic predisposing factorGenomeGenotypeGlaucomaGlaucoma SimplexGoalsHealthHeritabilityHistoryHumanIntraocular PressureKnowledgeLigand Binding ProteinLigand Binding Protein GeneLinkMT-bound tauMapsMiceMice MammalsModern ManMolecularMurineMusMutationNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural GanglionNeural degenerative DisordersNeuritic PlaquesNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationOcular HypertensionOcular TensionOpen-Angle GlaucomaOptic NervePOAGPathogenesisPathway interactionsPatientsPhysiologic Intraocular PressurePhysiopathologyPreA4Primary Open Angle GlaucomaPrimary Senile Degenerative DementiaProtease Nexin IIProtein BindingProtein PrecursorsProteinsPublic HealthRNA ExpressionRaceRacesRecording of previous eventsReporterResearchRetinaRetinal DiseasesRetinal DisorderRetinal Ganglion CellsRiskRisk FactorsRisk-associated variantRoleSecond Cranial NerveSelection CriteriaSenile PlaquesSerotypingSightSimple GlaucomaSingle Base PolymorphismSingle Nucleotide PolymorphismSourceSpecificityTestingTherapeutic InterventionTissuesTranscriptTranscriptionTranslatingUnited StatesVariantVariationVirusVisiona beta peptideabetaage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage groupage related neurodegenerationage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderagesaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderamyloid betaamyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) protein, humanamyloid beta plaqueamyloid-b plaqueamyloid-b proteinaβ plaquesbeta amyloid fibrilbiologicbound proteincored plaquedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiffuse plaquedisease riskdisorder riskeffective therapyeffective treatmentenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsgene locusgenetic locusgenetic risk factorgenome mutationgenome wide analysisgenome wide associationgenome wide association scangenome wide association studygenome wide studiesgenome-wide analysisgenome-wide identificationgenomewide association scangenomewide association studygenomic locationgenomic locusglaucomatoushigh riskhistorieshuman protease nexin 2inherited factorinsightintervention therapyintra-ocular pressuremembermicrotubule bound taumicrotubule-bound tauneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological degenerationneuronal degenerationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetocular hypertensivepathophysiologypathwaypreventpreventingprimary degenerative dementiapromoterpromotorprotease nexin 2protein structureprotein structuresproteins structurepublic health relevanceracialracial backgroundracial originretina diseaseretina disorderretinal ganglionretinopathyrisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle nucleotide variantsingle-cell RNA sequencingsocial rolesoluble amyloid precursor proteintangletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau Proteinstau factortranscriptomicsvision lossvisual functionvisual losswhole genome association analysiswhole genome association studyτ Proteins
Description preview
Abstract
Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their
axons. Damage from glaucoma is permanent and may cause irreversible blindness. Glaucoma is a major
public health problem in the United States and worldwide, where it is the leading cause of irreversible
blindness. Four classic risk…
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