grant
Forecasting influenza evolution on a heterogeneous immune landscape
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 15 Feb 2022Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAb-mediated immunityAb-mediated protectionAccountingAdultAdult HumanAffectAmino AcidsAntibody immunityAntibody protectionAntibody-mediated protectionAntigensAssayBioassayBiological AssayChildChild YouthChildren (0-21)CommunitiesComputer ModelsComputerized ModelsComputing MethodologiesDNA mutationDataEvolutionFerretsFrequenciesGenetic ChangeGenetic defectGenetic mutationGenomicsGenotypeGrippeHemagglutinationHeterogeneityHistoryHumanImmuneImmunesImmunityIndividualInfectionInfluenzaInfluenza HAInfluenza HemagglutininInfluenza VaccinesInfluenza VirusMapsMeasurementMeasuresMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsModelingModern ManMutationPersonsPhenotypePopulationRecording of previous eventsScientistSeasonsSpecificitySurface ProteinsSystemUpdateVaccinationVaccinesVariantVariationViralVirusVisualizationWorkadulthoodaminoacidantibody-mediated immunitycombatcomputational methodologycomputational methodscomputational modelingcomputational modelscomputer based methodcomputer based modelscomputer methodscomputerized modelingcomputing methodexperimentexperimental researchexperimental studyexperimentsfitnessflu HAflu hemagglutininflu surveillanceflu vaccineflu virus vaccinegenome mutationhistoriesimmunogenimprovedinfluenza surveillanceinfluenza viral HAinfluenza viral hemagglutinininfluenza virus HAinfluenza virus hemagglutinininfluenza virus vaccineinfluenzavirusinnovateinnovationinnovativeinteractive data visualizationinteractive visualizationkidsmeetingmeetingsmutantmutation scanningmutation screeningneutralizing antibodynew approachesnovel approachesnovel strategiesnovel strategyprotein functionresponseseasonal fluseasonal influenzavaccine against fluvaccine against influenzayoungster
Description preview
PROJECT SUMMARY
Influenza virus evolves rapidly to escape immunity elicited by prior infections and vaccinations. To combat this
evolution, the strains in the influenza vaccine are updated every season to keep pace with viral evolution.
However, it is currently difficult to accurately forecast which viral strain will dominate the coming season,…
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