grant
Follow-Up Studies of a Genome-Wide Association Analysis in Pima Indians
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years old6-Phosphofructo-2-kinase6PF2KATP-D-Fructose-6-phosphate 2-phosphotransferaseActive Follow-upAcuteAdipose tissueAdultAdult HumanAdult-Onset Diabetes MellitusAffectAkimel O'odhamAllelesAllelomorphsAmerican IndianAmerican Indian PopulationAmerican Indian groupAmerican Indian individualAmerican Indian peopleAmerican IndiansAssayAtrophicAtrophyBMIBMI percentileBMI z-scoreBWCRBasal MetabolismBasal Transcription FactorBasal metabolic rateBasal transcription factor genesBeta CellBindingBinding SitesBioassayBiologicalBiological AssayBiopsyBlood PlasmaBody TissuesBody fatBody mass indexC-EBP Nuclear ProteinC-EBP ProteinsC/EBPCAAT-Enhancer-Binding ProteinsCCAAT Sequence-Specific DNA-Binding ProteinsCCAAT-Enhancer-Binding ProteinsCDKN1CCDKN1C geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCaucasianCaucasian RaceCaucasiansCaucasoidCaucasoid RaceCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsChildhoodCholesterolClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemCollaborationsCombining SiteCommunitiesComplications of Diabetes MellitusCustomCyclin-Dependent Kinase Inhibitor 1C GeneDataData BasesDatabasesDiabetes ComplicationsDiabetes-Related ComplicationsDiabetic ComplicationsDiabetic Kidney DiseaseDiabetic NephropathyDiseaseDisorderEnergy ExpenditureEnergy MetabolismEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationExpenditureFastingFatty TissueFollow-Up StudiesFollowup StudiesFrequenciesFructoseGTExGWA studyGWASGenderGene ClusterGene ExpressionGene FrequencyGene TranscriptionGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenetic studyGenotypeGenotype-Tissue Expression ProjectGlucocorticoid ReceptorGlucocorticoidsHepaticHigh PrevalenceHumanHumulin RIndigenousIndividualInpatientsInsulinInsulin CellInsulin Secreting CellIntervening SequencesIntracellular Communication and SignalingIntronsIsoformsKIP2KIP2 GeneKetosis-Resistant Diabetes MellitusKidneyKidney GlomerulusKidney Urinary SystemKnock-outKnockoutLDLLDL LipoproteinsLeukemic CellLevuloseLinkage DisequilibriumLiverLow-Density LipoproteinsLuciferase ImmunologicLuciferasesMalpighian TuftMapsMaturity-Onset Diabetes MellitusMeasuresMeta-AnalysisMetabolicMiceMice MammalsMinorModern ManMolecular InteractionMurineMusMuscleMuscle AtrophyMuscle TissueMuscular AtrophyNIDDMNR3C1NR3C1 geneNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityOccidentalP57-Kip2 GenePersonsPhenotypePhosphofructokinase-2PhysiologicPhysiologicalPima IndianPlasmaPlasma SerumPopulationProtein IsoformsQTLQuantitative Trait LociQuetelet indexRNA ExpressionRNA SplicingRT-PCRReactive SiteRegular InsulinReportingResistanceReticuloendothelial System, Serum, PlasmaReverse Transcriptase Polymerase Chain ReactionRiskRisk-associated variantRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSiteSkeletal MuscleSlow-Onset Diabetes MellitusSouthwest U.S.Southwest USSouthwestern United StatesSplicingStable Diabetes MellitusStrains Cell LinesSystemT2 DMT2DT2DMTimeTissue SampleTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTribesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesTyrosine 3-MonooxygenaseTyrosine HydroxylaseVariantVariationVoluntary MuscleY Chromosomeactive followupadiposeadiposityadult onset diabetesadulthoodallelic frequencyallelic variantbeta-Lipoproteinsbiologicbiological signal transductioncell typecohortcorpulencecultured cell linecustomsdata basedesigndesigningentire genomeethnic subgroupethnicity groupfallsfastedfastsfollow upfollow-upfollowed upfollowupfull genomegene editing methodgene editing methodologygene editing strategygene editing techniquesgene-editing approachgenetic variantgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic datagenomic datasetgenomic variantgenomic variationglucose metabolismhepatic body systemhepatic organ systemin silicoindigenous communityinsulin secretionketosis resistant diabeteskidney biopsykidney glomerulimanufacturematurity onset diabetesmetabolic ratemuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmuscularnon-diabeticnondiabeticp57pediatricpromoterpromotorrenalrenal biopsyrenal glomerulusresistantresponseresting metabolic ratereverse transcriptase PCRrisk allelerisk generisk genotyperisk locirisk locusrisk variantscaffoldscaffoldingsocial roletraittranscription factortype 2 DMtype II DMtype two diabetesurban American Indianurban Indianurban Native Americanventilationwhite adipose tissuewhite racewhole genomewhole genome association analysiswhole genome association studyyellow adipose tissueβ-cellβ-cellsβCell
Description preview
Genetic studies in Indigenous people have been hampered by the lack of commercially available genotyping arrays which contain variation enriched or unique to this ethnic group, and the absence of publicly available genomic datasets that capture linkage disequilibrium for imputation in this population. To overcome these issues, we obtained…
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