grant
Focused ultrasound-enabled brain tumor liquid biopsy
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Jun 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202621+ years old3-D print3-D printer3D Print3D printer3D printingAD dementiaAbscissionAcousticsAddressAdoptionAdultAdult HumanAlgorithmsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnatomic SitesAnatomic structuresAnatomyAutomobile DrivingBiological MarkersBiopsyBloodBlood - brain barrier anatomyBlood CirculationBlood Reticuloendothelial SystemBlood-Brain BarrierBloodstreamBody TissuesBrainBrain CancerBrain DiseasesBrain DisordersBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCAT scanCT X RayCT XrayCT imagingCT scanCephalicClinicClinicalClinical ResearchClinical StudyClinical TrialsComputed TomographyCouplingCranialDevelopmentDevice DesignsDevicesDiagnosisEchographyEchotomographyEffectivenessElementsEncephalonEncephalon DiseasesEngineeringEnsureExcisionExtirpationFaceFeedbackFocused UltrasoundFrameless StereotaxyFriendsFundingFutureGlioblastomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHairHeadHemato-Encephalic BarrierHistologicHistologicallyHumanHydrocarbon oilsIndividualIntracranial CNS DisordersIntracranial Central Nervous System DisordersLiquid ParaffinLiquid PetrolatumLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant Tumor of the BrainMalignant neoplasm of brainMediatingMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedical UltrasoundMicrobubblesMineral OilModern ManMolecularMolecular DiagnosisMolecular FingerprintingMolecular ProfilingMolecular TargetMonitorNIBIBNMR ImagingNMR TomographyNational Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNeuronavigationNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresOutcomePatientsPerformancePhasePositionPositioning AttributePrecision carePrimary Brain NeoplasmsPrimary Brain TumorsPrimary Senile Degenerative DementiaProceduresPublic HealthRemovalResearchRiskSafetySamplingSonicationSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSystemTechniquesTestingTherapeutic AgentsTissuesTomodensitometryTransducersTranslatingTumor-DerivedUltrasonic ImagingUltrasonic TransducerUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUltrasound transducerUnited StatesUnited States National Institutes of HealthValidationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyZeugmatographyadulthoodanimal databio-markersbiologic markerbiomarkerbloodbrain barriercancer progressioncatscanclinical practiceclinical translationclinically translatablecomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographydesigndesign and constructdesign and constructiondesigningdetectordevelopmentaldiagnostic abilitydiagnostic capabilitydiagnostic powerdiagnostic ultrasounddiagnostic utilitydiagnostic valuedrivingfacesfacialfirst in manfirst-in-humanglioblastoma multiformeimprovedindividual patientindividualized careindividualized patient careinnovateinnovationinnovativelenslensesliquid biopsymanufacturemolecular profilemolecular signaturemouse modelmultidisciplinarymurine modelneoplasm progressionneoplastic progressionneural imagingneuro-imagingneuroimagingneurological diseaseneurological imagingneurosurgerynext generationnon-contrast CTnon-human primatenoncontrast CTnoncontrast computed tomographynonhuman primatenovelpersonalized carepersonalized patient carepig modelpiglet modelporcine modelprimary degenerative dementiaresectionresponse to therapyresponse to treatmentrisk minimizationsafety and feasibilitysenile dementia of the Alzheimer typesonogramsonographysound measurementspecific biomarkersspongioblastoma multiformesuccesssurgeryswine modeltechnology platformtechnology systemtherapeutic responsetherapy responsethree dimensional printingtreatment responsetreatment responsivenesstumortumor diagnosistumor progressiontumors in the brainultrasoundultrasound imagingultrasound scanningvalidationswearablewearable devicewearable electronicswearable systemwearable technologywearable toolwearables
Description preview
PROJECT SUMMARY/ABSTRACT
There is an unmet critical need for techniques that achieve noninvasive molecular diagnosis of brain tumors.
Our group is addressing this unmet need by introducing and developing the focused ultrasound (FUS)-enabled
blood-based liquid biopsy technique, which we call sonobiopsy. NIH/NIBIB support (R01EB030102, funding…
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