grant
Fluid Biomarker Core
Organization UNIVERSITY OF NEW MEXICO HEALTH SCIS CTRLocation ALBUQUERQUE, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDAddressAlbuminsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAmentiaAmerican Indian PopulationAmerican Indian groupAmerican Indian individualAmerican Indian peopleAmerican IndiansAssayAstroproteinAutopsyBBB permeabilizationBBB permeableBioassayBiologicalBiological AssayBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood VesselsBlood specimenCancer Center Planning GrantCaringCaucasianCaucasian RaceCaucasiansCaucasoidCaucasoid RaceCausalityCerebrospinal FluidClassificationClinicalClinical TrialsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunitiesDataData BasesDatabasesDementiaDevelopmentDiagnosisDiagnosticDisturbance in cognitionEarly identificationEducationEducational aspectsEsteroproteasesEtiologyFDA approvedFreezingFutureGFA-ProteinGFAPGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsGrowth AgentsGrowth FactorGrowth SubstancesHispanicHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsImageImpaired cognitionIncidenceIndividualIndividuals from minorityIndividuals of minorityInflammationInflammatoryInfrastructureInjuryInvestigatorsL-ThreonineLatinoLatino PopulationLatino groupLatino individualLatino peopleLatinosLifeLightLiquid substanceLumbar PunctureMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMinority GroupsMinority PeopleMinority PopulationMinority individualNMR ImagingNMR TomographyNerve DegenerationNeuron DegenerationNeuropsychologic TestsNeuropsychological TestsNew MexicoNuclear Magnetic Resonance ImagingOccidentalP20 GrantPETPET ScanPET imagingPETSCANPETTParticipantPatientsPeptidasesPeptide HydrolasesPhasePhotoradiationPlasmaPlasma SerumPopulationPopulation HeterogeneityPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrevalencePreventionPrimary Senile Degenerative DementiaPrognosisProtease GeneProteasesProteinasesProteinsProteins Growth FactorsProteolytic EnzymesRad.-PETResearchResearch PersonnelResearch ResourcesResearchersResource SharingResourcesReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleRuralRural PopulationRural groupRural peopleSamplingSpinal PunctureSystematicsTest ResultThreonineTrainingUnderrepresented Ethnic MinorityUnderrepresented MinorityUrban CommunityVascular DiseasesVascular DisorderWorkZeugmatographyalzheimer riskbio-markersbiobankbiologicbiologic markerbiomarkerbiorepositoryblood vessel disorderblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrier permeabilizationbloodbrain barrier permeablecardiac disease induced cognitive impairmentcausationcerebral spinal fluidcerebrovascular contribution to cognitive impairment and dementiacognitive dysfunctioncognitive losscohortcontrast enhancedcostcytokinedata basedementia riskdevelopmentaldisease causationdiverse populationsearly onsetearly screeningfluidheterogeneous populationimagingimprovedindexinginjuriesinstrumentliquidmixed dementiamixed etiology dementiamixed pathology dementiamixed type dementiamultiple etiology dementiamultiple pathology dementiamultiple type dementianecropsyneural degenerationneural inflammationneuro-vascularneurodegenerationneurodegenerativeneurofilamentneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationneurovascularnext generationoutreachp-taup-τphospho-tauphospho-τphosphorylated taupopulation diversitypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of taupostmortemposttranslational modification of tauprimary degenerative dementiarecruitrisk factor for dementiarisk for dementiarural arearural individualrural locationrural regionrural under representedrural underrepresentedsample collectionscreeningscreeningssenile dementia of the Alzheimer typesocial rolespecimen collectionspinal fluidsubstantia albatau phosphorylationtau posttranslational modificationtau-1treatment trialunder-representation of minoritiesunder-represented minorityunderrepresentation of minoritiesvascularvascular cognitive impairment and dementiavascular contribution to impairment or dementiavascular contributions to cognition/dementiavascular contributions to cognitive decline and dementiavascular contributions to cognitive impairment and dementiavascular dysfunctionvascular inflammationvasculopathywhite matterwhite matter damagewhite matter injurywhite raceτ phosphorylation
Description preview
PROJECT SUMMARY – BIOMARKER (FLUID) CORE (BMC)
During the NMeADRC, we identified specific MRI- and fluid- based biomarkers to classify ADRDs into vascular
and neurodegenerative contributions. Currently, AD diagnosis uses the NIA/AA formula with A+ (A), T+
(phosphorylated tau at threonine 181), and N+ (neurodegeneration) as surrogates in…
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