grant
Flexible multivariate models for linking multi-scale connectome and genome data in Alzheimer’s disease and related disorders
Organization GEORGIA STATE UNIVERSITYLocation ATLANTA, UNITED STATESPosted 1 Jun 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026AD and related dementiaAD dementiaAD related dementiaADRDActive Follow-upAddressAlgorithmsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaArteriosclerotic DementiaBehaviorBehavioralBenchmarkingBest Practice AnalysisBiologicalBlood VesselsBrainBrain Nervous SystemBrain imagingBrain regionCandidate Disease GeneCandidate GeneCategoriesCausalityClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunitiesComplexComputer softwareCoupledDataData CollectionDegenerative Neurologic DisordersDementiaDiagnosticDimensionsDiseaseDisorderDisturbance in cognitionEarly DiagnosisEncephalonEtiologyEvaluationFamilyFunctional MRIFunctional Magnetic Resonance ImagingFutureGene variantGenerationsGenesGeneticGenomeGenomicsGoalsGroupingImageImpaired cognitionIndividualInvestigatorsJointsLinear ModelsLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModalityModelingNMR ImagingNMR TomographyNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNon-linear ModelsNonlinear ModelsNuclear Magnetic Resonance ImagingOutcomeOutputPathologicPathologyPathway interactionsPerformancePrimary Senile Degenerative DementiaResearch PersonnelResearchersRestRunningSamplingSingle Base PolymorphismSingle Nucleotide PolymorphismSoftwareSourceStructureSubgroupTimeVascular DementiaWorkZeugmatographyactive followupallelic variantanonymous databenchmarkbiologicblindbrain visualizationcausationcerebrovascular contributions to dementiacognitive dysfunctioncognitive lossconnectomedata anonymizationdata complexitydata fusiondeep learningdeep learning methoddeep learning strategydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisease causationearly detectionfMRIflexibilityflexiblefollow upfollow-upfollowed upfollowupgenetic variantgenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationgenomic datagenomic datasetgenomic signaturegenomic variantgroupingshigh dimensional dataimagingimprovedinterestinteroperabilitylarge data setslarge datasetslongitudinal data setlongitudinal datasetmulti-modal datamulti-modal datasetsmulti-modal neuro-imagingmulti-modalitymulti-scale datamultidimensional datamultidimensional datasetsmultimodal datamultimodal data fusionmultimodal datasetsmultimodal fusionmultimodal modelingmultimodal neuroimagingmultimodalitymultiple data typesmultiscale dataneural degenerationneural imagingneuro-imagingneurobehavioralneurobiologicalneurodegenerationneurodegenerativeneurodegenerative illnessneuroimagingneurological degenerationneurological imagingneuronal degenerationnext generationnovelpathology imagingpathwaypolygenetic risk scorespolygenic risk scoreprimary degenerative dementiasenile dementia of the Alzheimer typesingle nucleotide variantspatial and temporalspatial temporalspatiotemporalsubcortical ischemiasubcortical ischemic vascular diseasetooluser-friendlyvascularvascular contributions in dementiavascular contributions to dementiavascular related dementia
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Project Summary/Abstract
In the field of Alzheimer's and related dementias (ADRD), while multimodal data collection is common, most
approaches still separately analyze and then combine the data. There is much less work on methods that can
perform joint decomposition of multimodal neuroimaging and genomic data, despite considerable promise. Most…
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