grant
Fanconi Anemia Pathway
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025BACH1BACH1 geneBRCA1BRCA1 Gene ProductBRCA1 ProteinBRCA1 geneBindingBiochemicalBiologicalBreast CancerBreast Cancer 1 GeneBreast Cancer 1 Gene ProductBreast Cancer Type 1 Susceptibility GeneBreast Cancer Type 1 Susceptibility ProteinBreast-Ovarian Cancer ProteinChromosomal InstabilityChromosome InstabilityClinicalComplementComplement ProteinsCongenital PancytopeniaDNADNA DamageDNA Damage RepairDNA HelicasesDNA InjuryDNA RepairDNA ReplicationDNA StructureDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA metabolismDNA mutationDNA replication forkDNA unwinding enzymeDataDeoxyribonucleic AcidDiseaseDisorderDouble Strand Break RepairEarly Onset Gene Breast Cancer 1Early Onset Protein Breast Cancer 1FA DNA repair pathwayFA-mediated DNA repair pathwayFanconi AnemiaFanconi Anemia pathwayFanconi PanmyelopathyFanconi anemia DNA repair pathwayFanconi anemia repair pathwayFanconi dysplasiaFanconi's AnemiaGeneticGenetic ChangeGenetic defectGenetic mutationHereditary Breast Cancer 1LengthLinkMalignant Breast NeoplasmMismatch RepairMolecularMolecular InteractionMutateMutationPatientsPhenotypePlayPost-Replication Mismatch RepairPrimary Erythroid HypoplasiaProteinsRNF53RecombinantsRoleSS DNA BPSingle-Stranded DNA-Binding ProteinSpinal ColumnSpineSubstrate SpecificityTailUnscheduled DNA SynthesisVariantVariationVertebral columnWorkbackbonebiologicbrca 1 genecomplementationcongenital aplastic anemiacrosslinkearly onsetgenome mutationhelicasehomologous recombinationinsightmalignant breast tumornovelprotein complexrepairrepairedreplication forkreplication stressresponsesocial role
Description preview
Our recent work has focused on the roles of the FANCJ helicase in the DNA damage response. Mutations in the BRCA1-associated helicase BACH1 have been associated with early-onset breast cancer and cellular data suggest a role of the helicase in double strand break repair and checkpoint control. Recently, BACH1 (FANCJ) has been genetically linked…
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