grant
Facilitating the Implementation of Population-wide Genomic Screening (FOCUS)
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 5 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAddressAdministratorAdoptionAdultAdult HumanApplication ContextAttentionCardiovascular DiseasesCharacteristicsClinicalClinical ManagementCluster randomization trialCluster randomized trialCommunitiesConsolidated Framework for Implementation ResearchConsolidated Framework for Implementation ScienceConsolidated Framework for Implementing ChangeDataDiseaseDisorderEngineeringEssential HypercholesterolemiaEvaluationFamilial Breast and Ovarian Cancer SyndromeFamilial HypercholesterolemiaFamilial Nonpolyposis Colon CancerFamiliar Malignant NeoplasmFamilyFamily memberGenesGenomic TestingGenomic medicineGenomicsGoalsGuidelinesHNPCCHealth CareHereditary Breast and Ovarian CancerHereditary Breast and Ovarian Cancer SyndromeHereditary CancerHereditary Colo-rectal Endometrial Cancer SyndromeHereditary Colorectal Endometrial Cancer SyndromeHereditary Defective Mismatch Repair SyndromeHereditary Malignant NeoplasmHereditary Non-Polyposis Colon CancerHereditary Nonpolyposis Colo-rectal CancerHereditary Nonpolyposis Colo-rectal NeoplasmsHereditary Nonpolyposis Colon CancerHereditary Nonpolyposis Colorectal CancerHereditary Nonpolyposis Colorectal NeoplasmsHybridsHyperbetalipoproteinemiaHyperlipoproteinemia Type 2Hyperlipoproteinemia Type IIIndividualInterviewKnowledgeLS/HNPCCLynch SyndromeMapsMethodsMorbidityMorbidity - disease rateNHGRINational Academy of SciencesNational Center for Human Genome ResearchNational Human Genome Research InstituteNeeds AssessmentOrganization ChartsOutcomeParticipantPatientsPersonsPopulationPopulation CharacteristicsPopulation GrowthPrecision HealthProceduresProcessProtocolProtocols documentationProviderPublic HealthRE-AIMReach, Effectiveness, Adoption, Implementation, and MaintenanceRecommendationRiskScreening procedureSiteStandardizationStrategic visionStructureTestingType 2 HyperlipidemiaType II HyperlipidemiaUnited States National Academy of Sciencesadulthoodbarriers to implementationcardiovascular disordercontextual factorscostdesigndesigningdisease causing variantdisease preventiondisease-causing alleledisease-causing mutationdisorder preventionfacilitators to implementationfamilial cancerfamilial hyperbetalipoproteinemiafamilial hypercholesteremiafamilial hyperlipoproteinemia type 2familial hyperlipoproteinemia type IIfield based datafield learningfield studyfield testgenetic counselorgenome based testinggenome medicinegenome testinggenomic DNA testinggenomic based testinggenomic clinical testinggenomic profiling testinggenomic screening testhereditary non-polyposis colo-rectal cancerhereditary non-polyposis colorectal cancerhereditary riskhigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhuman centered designimplementation barriersimplementation challengesimplementation facilitationimplementation facilitatorsimplementation processimplementation strategyimprovedmembermortalityorganizational structurepathogenic allelepathogenic variantpatient populationpopulation basedpopulation genomic screeningpopulation healthpopulation-based genomic screeningpopulation-level genomic screeningpopulation-wide genomic screeningprecision medicineprecision-based medicineprogramsprototyperapid growthreach, efficacy, adoption, implementation, and maintenancerecruitscreeningscreening programscreening toolsscreeningsstrategies for implementationtooltrial design
Description preview
Population-wide genomic screening (PGS) for Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, and Familial Hypercholesterolemia offers great promise in identifying the 1-2% of the population that unknowingly carries a pathogenic variant that puts them at elevated risk for serious, yet preventable disease. Rapidly decreasing sequencing…
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