grant
Facilitating the Chemistry of Fluorosequencing
Organization UNIVERSITY OF TEXAS AT AUSTINLocation AUSTIN, UNITED STATESPosted 1 May 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025Amino Acid Sequence DeterminationsAmino AcidsBODIPYC-terminalChemicalsChemistryCollaborationsColoring AgentsData BasesDatabasesDiagnosticDiseaseDisorderDyesFRETFluorescence Resonance Energy TransferFörster Resonance Energy TransferGenerationsGenomicsHealthIndividualL-LysineLabelLysineMethodsMethylationMicroscopeN-terminalNH2-terminalNucleic Acid Sequencing Molecular BiologyNucleic acid sequencingPeptide Sequence DeterminationPeptidesPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein AnalysisProtein ModificationProtein Sequence DeterminationsProtein SequencingProtein Sequencing Molecular BiologyProteinsProteomicsReportingRunningSamplingSeriesTechniquesTechnologyTimeUbiquitilationUbiquitinationUbiquitinoylationWorkaminoacidbasebasesdata basedesigndesigningfluorophoreimage-based methodimaging methodimaging modalityimprovednano porenanoporepeptide aminoacid sequencepeptide sequenceprotein aminoacid sequencesequencing platformsingle moleculeubiquinationubiquitin conjugation
Description preview
ABSTRACT
While advances in nucleic acid sequencing to achieve parallel and single molecule analysis have been
astounding, analogous techniques for peptide/protein sequencing are lacking. Tandem mass-spec analysis still
requires millions of copies of a protein and is inherently serial rather than parallel. Thus, the current approaches
being applied…
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