grant

Extreme Heat and Acute Myocardial Infarction: Effect Modifications by Sex, Medical History, and Air Pollution

Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 4 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldACE InhibitorsAcute myocardial infarctAcute myocardial infarctionAddressAdultAdult HumanAgeAirAir PollutantsAir PollutionAngiotensin I-Converting Enzyme InhibitorsAngiotensin ReceptorAngiotensin-Converting Enzyme AntagonistsAngiotensin-Converting Enzyme InhibitorsBlood PlateletsCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Channel BlockersCalcium Channel Blocking DrugsCalcium Ion ChannelsCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCause of DeathCessation of lifeChronicCoupledCross-Over DesignsCrossover DesignDataData SetDeathDiabetes MellitusDisparitiesDisparityDiureticsDrugsDyslipidemiasEnvironmental ExposureEnvironmental HazardsEpidemiological dataEpidemiologyEpidemiology dataEvaluation of Risk FactorsEventExogenous Calcium AntagonistsExogenous Calcium BlockadersExogenous Calcium InhibitorsExposure toGenderGermanGerman populationHeart VascularHeat WavesHigh temperature of physical objectHospital MortalityHospitalsHumidityHypertensionImpoverishedIn-house MortalitiesInhospital MortalityIntakeInterviewKininase II AntagonistsKininase II InhibitorsKnowledgeLinkMarrow plateletMedical HistoryMedical RecordsMedicationMental DepressionModelingModificationMorbidityMorbidity - disease rateNon-linear ModelsNonlinear ModelsO3O3 exposureOutcomeOzonePM2.5ParticulatePatientsPersonal Medical HistoryPersonal Medical History EpidemiologyPersonsPharmaceutical PreparationsPhysiologicPhysiologicalPlateletsPolicy MakerPopulationPovertyPreventative strategyPrevention strategyPreventive strategyProbabilityPublic HealthReceptor ProteinRecommendationRecoveryRegistriesResearchResolutionRiskRisk EstimateRisk FactorsRoleSES disparitySmokingSocio-economic statusSocioeconomic StatusSubgroupTemperatureThrombocytesTimeVDCCVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderVoltage-Dependent Calcium ChannelsVulnerable PopulationsWomanWorkadult youthadulthoodagedagescalcium antagonistcirculatory systemcohortdepressiondesigndesigningdiabetesdisabilitydrug/agentelderly patientepidemiologicepidemiologic dataepidemiologicalevidence baseextreme heatextreme temperaturefine particlesfine particulate matterground-level ozoneheatwavehigh blood pressurehigh riskhigh temperaturehospitalization rateshyperpiesiahyperpiesishypertensive diseasehypertensive disorderindexinglow SESlow socio-economic positionlow socio-economic statuslow socioeconomic positionlow socioeconomic statusmenmortalityobservational cohort studyolder adultolder adulthoodolder patientozone exposurepreventpreventingprospectivereceptorresolutionssexsocial rolesocio-economicsocio-economic disparitysocio-economic inequalitysocio-economic inequitysocio-economic positionsocio-economicallysocioeconomic disparitysocioeconomic inequalitysocioeconomic inequitysocioeconomic positionsocioeconomicallysocioeconomicsspatial and temporalspatial temporalspatiotemporaltropospheric O3tropospheric ozonevulnerable groupvulnerable individualvulnerable peopleyoung adultyoung adult ageyoung adulthoodyoung manyoung menyoung woman
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Description preview

Acute myocardial infarction (AMI), a major cause of cardiovascular disability and death in the US, can be triggered by environmental exposures like heat, cold, and fine particulate air pollution (PM2.5). However, less is known about whether temperature variability, elevated temperature-humidity metrics, or ground-level ozone exposures could also…

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Extreme Heat and Acute Myocardial Infarction: Effect Modifications by Sex, Medical History, and Air Pollution — YALE UNI | Dev Procure