grant
Extrafollicular B cell response regulation during influenza infection
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 10 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY202519S Gamma Globulin7S Gamma GlobulinAdjuvantAdoptive TransferAffectAffinityAgonistAirway infectionsAldesleukin GeneAntibodiesAntibody ResponseAntigensB Cell ProliferationB blood cellsB cellB cellsB-Cell ActivationB-CellsB-LymphocytesB-cellBlood Plasma CellBody TissuesCD25Cell BodyCell Communication and SignalingCell SignalingCellsComplexContracting OpportunitiesContractsDevelopmentEarly identificationFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGenetic TranscriptionGerminal CenterGrippeHomoHumoral ImmunitiesIFNIL-2 GeneIL2IL2 geneIL2RIL2RAIL2RA geneIgAIgGIgMImmuneImmune signalingImmunesImmunityImmunizationImmunoglobulin AImmunoglobulin GImmunoglobulin MInfectionInfluenzaInfluenza HAInfluenza HemagglutininInfluenza VaccinesInfluenza VirusInnate Immune ResponseInterferonsInterleukin 2 Precursor GeneInterleukin-2 GeneIntracellular Communication and SignalingKnowledgeLearningLungLung Respiratory SystemLymphLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMediatingMemoryMemory B CellMemory B-LymphocyteMiceMice MammalsMurineMusPhenotypePlasma CellsPlasmablastPlasmacytesPopulationProliferatingPulmonary Body SystemPulmonary Organ SystemRNA ExpressionRegulationRespiratory InfectionsRespiratory SystemRespiratory Tract InfectionsRespiratory TractsRespiratory tract structureRoleShapesSignal TransductionSignal Transduction SystemsSignalingSiteStimulusStructure of germinal center of lymph nodeT-Cell Growth Factor GeneTCGF GeneTCGFRTLR3TLR3 geneTLR7TLR7 geneTestingTimeTissuesToll-Like Receptor 3Toll-Like Receptor 7TranscriptTranscriptionUpregulationVaccinationVaccine DesignVaccinesViralVirusWorkactivated B cellsadaptive immunityantibody-based immunityarmbiological signal transductioncytokinedevelopmentaldraining lymph nodeexperienceflow cytophotometryflu HAflu hemagglutininflu infectionflu vaccineflu virus infectionflu virus vaccineimmune response to vaccinationimmune response to vaccinesimmunogeninfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza viral HAinfluenza viral hemagglutinininfluenza virus HAinfluenza virus hemagglutinininfluenza virus infectioninfluenza virus vaccineinfluenzaviruslymph glandlymph nodeslymphatic fluidlymphnodesmouse modelmurine modelnovelplasmocyteregional lymph noderesponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolevaccine against fluvaccine against influenzavaccine associated immune responsevaccine immune responsevaccine immunogenicityvaccine induced immune response
Description preview
PROJECT SUMMARY
Infection-induced B cell activation occurs in the context of complex innate immune responses, including
the elaboration of cytokines, and the remodeling of secondary lymph tissues draining sites of infection. Our
long-term objective is to determine how optimal protective humoral immunity to infections is induced and
maintained.…
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