grant
Extracellular vesicles in Environmental Epidemiology Studies of Aging
Organization HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTHLocation BOSTON, UNITED STATESPosted 6 Aug 2024Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20243D cell culture3D cultureAccelerationActive Follow-upAddressAdverse effectsAffectAgeAgingAirAir PollutionAmentiaAwardBindingBiologicalBiological MarkersBiologyBloodBlood CirculationBlood Reticuloendothelial SystemBlood SampleBlood specimenBloodstreamBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsChronic DiseaseChronic IllnessClinicalClinical DataCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalCohort StudiesCommunicationConcurrent StudiesDataData ScienceDementiaDependenceDeteriorationDisturbance in cognitionDysfunctionEarly identificationEncephalonEnvironmental EpidemiologyEnvironmental ExposureEnvironmental HealthEnvironmental Health ScienceEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchFunctional disorderFundingFutureHealthHumanHuman FigureHuman bodyImpaired cognitionIn VitroInfluentialsIntracellular Communication and SignalingInvestigatorsLaboratoriesLeadLeadershipLifeLungLung Respiratory SystemMediatingMembraneMethodsMicro RNAMicroRNAsModelingModern ManMolecularMolecular InteractionNational Institutes of HealthNerve DegenerationNeuron DegenerationOrganOrganoidsOutcomeParticulatePatternPb elementPhysiopathologyPollutionProcessPublic HealthPublicationsResearch PersonnelResearchersRoleRouteScientific PublicationSeminalSeriesSightSignal TransductionSignal Transduction SystemsSignalingSourceSurfaceSystemTechniquesTimeUnited States National Institutes of HealthVisionWorkactive followupage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentaged brainagesaging brainbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbrain healthbronchial epitheliumcell culturecell culturescell typechronic disordercognitive dysfunctioncognitive functioncognitive lossepidemiologic investigationepidemiology studyextracellular vesiclesflexibilityflexiblefollow upfollow-upfollowed upfollowupheavy metal Pbheavy metal leadinnovateinnovationinnovativeinterestmembrane structuremiRNAmiRNAsnano sizednanosizedneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnovelpathophysiologypre-clinicalpreclinicalpreventpreventingprogramspulmonaryresponsesocial rolestemthree dimensional cell culturetoolvesicle releasevesicular releasevisual function
Description preview
SUMMARY
Through this RIVER proposal, I seek support to characterize and understand early biological responses that
anticipate age-related disease, which typically develops from exposures that occurred much earlier in life. My
primary focus will be on the effects of air pollution on accelerated brain aging, a major interest of my lab.
Ambient air…
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