grant
Extracellular vesicles as nanotheranostic platform in neuroinflammation
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 15 Sept 2017Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20258-Hydroxyquinoline8-Oxyquinoline8-QuinolinolAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseApoplexyApoptoticAreaBehavioralBiodistributionBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBrain Vascular AccidentCAT scanCT X RayCT XrayCT imagingCT scanCancersCell BodyCell Communication and SignalingCell SignalingCell SurvivalCell TherapyCell ViabilityCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChemicalsClinicalClinical TrialsCommunitiesComplexComputed TomographyContrast AgentContrast DrugsContrast MediaD-MannoseDegenerative ArthritisDegenerative polyarthritisDiabetes MellitusDiagnosticDiseaseDisorderDisseminated SclerosisEAEElectroporationErythrocupreinEthicsExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisFaceFe oxideFormulationFreezingFutureGadoliniumGametesGd elementGehrig's DiseaseGerm CellsGerm-Line CellsGlycansGoalsHalf-LifeHemocupreinHomingImageImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInflammationInflammatoryIntracellular Communication and SignalingInvestigatorsIschemic HeartIschemic Heart DiseaseIschemic myocardiumLabelLateral SclerosisLinkLipidsLogisticsLou Gehrig DiseaseLuciferase ImmunologicLuciferasesMR ImagingMR TomographyMRIMRIsMS patientMacrophageMagnetic Nanoparticle imagingMagnetic Particle ImagingMagnetic Resonance ImagingMagnetismMalignant NeoplasmsMalignant TumorMannopyranoseMannopyranosideMannoseMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicineMembraneMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMethodsModalityMultiple SclerosisMultipotent Stem CellsMyocardial IschemiaMφNMR ImagingNMR TomographyNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNuclear Magnetic Resonance ImagingOsteoarthritisOsteoarthrosisOutcome MeasureOxineOxyquinolOxyquinolinePETPET ScanPET imagingPETSCANPETTPhasePhotonsPluripotent Stem CellsPolysaccharidesPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPre-Clinical ModelPreclinical ModelsPreparationPrimary Lateral SclerosisProductionProgenitor CellsPropertyRad.-PETRadiopaque MediaRegulatory approvalReporter GenesReproductive CellsResearch PersonnelResearch ResourcesResearchersResourcesRouteSafetySex CellSignal TransductionSignal Transduction SystemsSignalingSiteSpecificityStrokeStromal CellsSuperoxide DismutaseTechniquesTestingTherapeuticTherapeutic AgentsTissuesTomodensitometryTracerTransgenic MiceTransgenic OrganismsUncertaintyValidationVesicleX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyZeugmatographyautoimmune encephalomyelitisbiological signal transductionbioluminescence imagingbioluminescent imagingbrain attackcardiac ischemiacatscancell based interventioncell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular therapeuticcellular therapycerebral vascular accidentcerebrovascular accidentchelationclinical translationclinically translatablecolcotharcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycontrast imagingcoronary ischemiacostcytocupreindegenerative joint diseasediabetesdoubtelectroporative deliveryethicalextracellular vesiclesfacesfacialferric oxidegene electrotransfergold nano particlegold nanoparticleheart ischemiahypertrophic arthritisimagingimaging agentimaging in vivoimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoin vivo imaginginitial cellinsular sclerosisinterestiron oxidelipophilicitymagneticmalignancymeasurable outcomemembrane structuremesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmolecular imagingmolecule imagingmouse modelmultiple sclerosis patientmultipotent progenitormultipotent progenitor cellmurine modelmyocardial ischemia/hypoxiamyocardium ischemianano goldnano-theranosticsnanoGoldnanotheranosticsneoplasm/cancerneural inflammationneuroinflammationneuroinflammatoryneurological diseaseneuroprotectionneuroprotectivenon-contrast CTnoncontrast CTnoncontrast computed tomographyoutcome measurementoverexpressoverexpressionpatients with MSpatients with multiple sclerosispeople with Multiple sclerosispluripotent progenitorpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprecision medicineprecision-based medicinepreparationsprogenitor cell based therapyprogenitor cell therapyprogenitor cell treatmentprogenitor therapyprogenitor treatmentradiolabelradiolabelsradiotracerred iron oxideregulatory authorizationregulatory certificationregulatory clearancesexual cellstem and progenitor cell therapystem cell based therapystem cell mediated therapystem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentstem cellsstrokedstrokessuperparamagneticsuperparamagnetismtherapeutic outcometherapy outcometomographytransgenictumorigenicvalidation studiesvalidations
Description preview
Mesenchymal stem cells (MSCs) are the most widely used type of cells in stem cell therapy, with over 1,000
registered clinical trials primarily focused on immunosuppression of inflammatory disease. “MSCs” are often
termed “medicinal stem cells”, as they secrete multiple beneficial factors in the form of extracellular vesicles
(EVs) that have…
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