grant
Extracellular Matrix Regulation of Inflammatory Signaling in Tendon
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 5 Apr 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAddressAnimal ModelAnimal Models and Related StudiesAutomobile DrivingB-Cell ActivationBeta Proprotein Interleukin 1Body TissuesCachectin ReceptorsCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCell-Extracellular MatrixCellsChemicalsChronicClinical TreatmentCollagenConsultCouplingCytokine ReceptorsDevelopmentDiseaseDisorderECMEngineeringEnhancersEnvironmentExhibitsExposure toExtracellular MatrixFibroblastsGene ExpressionGenesGoalsHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1RIL1R1IL1R1 geneIL1RAIL1βImmunoglobulin Enhancer-Binding ProteinIn SituInflammationInflammatoryInflammatory ResponseInterleukin 1betaInterleukin-1 betaInterleukin-1βIntracellular Communication and SignalingInvestigationKnowledgeLightMeasuresMechanicsMembraneModern ManMolecularMusculoskeletal DiseasesNF-kBNF-kappa BNF-kappaBNFKBNuclearNuclear Factor kappa BNuclear Transcription Factor NF-kBOutcomePathogenesisPathogenicityPathologicPathologyPatient CarePatient Care DeliveryPatientsPhenotypePhotoradiationPolymersPreinterleukin 1 BetaPrimary CarePropertyPublishingReceptor ProteinRegulationReporterResearchRiskRoleSignal TransductionSignal Transduction SystemsSignalingStimulantTNF Receptor Family ProteinTNF Receptor SuperfamilyTNF ReceptorsTNFRTendinitisTendinopathyTendon structureTendonitisTendonsTherapeuticTissuesTranscription Factor NF-kBTransfectionTranslationsTumor Necrosis Factor ReceptorTumor Necrosis Factor Receptor FamilyTumor Necrosis Factor Receptor SuperfamilyVisualizationWorkactivated B cellsbiological signal transductioncantilevercare for patientscare of patientscaring for patientscell behaviorcell culturecell culturescellular behaviorclinical interventionclinical therapyconsultscytokinedevelopmentaldrivinghealingimprovedin vivoinsightkappa B Enhancer Binding Proteinmechanicmechanicalmechanical propertiesmembrane structuremicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemmodel of animalmusculoskeletal disordernew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapynuclear factor kappa betapatient populationpolymerpolymericpolymerizationreceptorsocial roletherapeutic agent developmenttherapeutic developmenttherapeutic targetthree dimensionaltissue culturetranslationtrial regimentrial treatment
Description preview
Abstract
Twenty percent of all primary care consults are related to musculoskeletal diseases; 30% of these are
associated with tendinopathies. Pathogenesis of tendinopathy includes increased inflammatory signaling and
extracellular matrix (ECM) remodeling. This remodeling leads to softer tendinopathic tendons, increasing the
risk of tearing. Yet…
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