grant
Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 24 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldAccountingAdultAdult HumanAmerican Indian PopulationAmerican Indian groupAmerican Indian individualAmerican Indian peopleAmerican IndiansArsenicBangladeshBiologicalBiologyBlack AmericanCandidate Disease GeneCandidate GeneCardiac DiseasesCardiac DisordersCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCessation of lifeChinese AmericanCitiesClinicalCohort StudiesConcurrent StudiesCoronary DiseaseCoronary heart diseaseDataData PoolingDeathDevelopmentDiseaseDisease PathwayDisorderDoseElementsEnvironmental ExposureEnvironmental FactorEnvironmental HealthEnvironmental Health ScienceEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchExposure toFamily StudyGWA studyGWASGene variantGenesGeneticGenetic MarkersGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGenetic studyGoalsHealthHeartHeart DiseasesHeart VascularHispanic AmericansIndividualInherited PredispositionInherited SusceptibilityKnowledgeLongitudinal StudiesMasksMeasurementMeasuresMediatingMediationMetal exposureMetalsMethodsModelingMolecular WeightMonitorMulti-Ethnic Study of AtherosclerosisNIEHSNational Institute of Environmental Health SciencesNegotiatingNegotiationPathway interactionsPatternPersonsPlayPopulationPopulation HeterogeneityPreventionProspective cohortProspective, cohort studyPublic HealthReportingReproducibilityResearchResearch ResourcesResourcesRiskRisk FactorsRoleSample SizeSamplingSampling StudiesStrategic PlanningSubgroupTestingToxic effectToxicitiesVariantVariationadulthoodallelic variantarsenicsbiologiccardiac disease riskcardiac disorder riskcaucasian Americancirculatory systemcohortcoronary disorderdevelopmentaldisabilitydisease riskdisorder riskdiverse populationsenvironmental riskepidemiologic investigationepidemiology studyexposure to metalgene biomarkergene expression biomarkergene interactiongene markergene signature biomarkergenetic biomarkergenetic etiologygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic variantground watergroundwaterhealth dataheart disease riskheart disorderheart disorder riskheterogeneous populationhigh risk grouphigh risk individualhigh risk peoplehigh risk populationimprovedinsightlong-term studylongitudinal outcome studiesmembermetabolism measurementmetabolomicsmetabonomicsmortalitynovelpathwaypopulation diversitypreventpreventingprospectiverecruitresponsesocial rolestudy populationtoxic metaltraiturinarywhite Americanwhole genome association analysiswhole genome association study
Description preview
Coronary heart disease (CHD) is the leading cause of mortality and disability worldwide, and accounts for 13%
of global deaths and 370,000 deaths annually in the US. Accumulating evidence suggests exposure to inorganic
arsenic (As) and other (often co-occurring) toxic metals may be an independent risk factor for CHD. Although
most individuals are…
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