grant
Exposing synthetic lethal vulnerabilities in EBV-positive AIDS-NHL through novel replication dependency factors
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 4 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAIDS lymphomaAIDS-Associated LymphomaAIDS-Related LymphomaAIDS/HIVAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressB blood cellsB cellB cellsB lymphomaB-Cell ActivationB-Cell LymphomasB-CellsB-LymphocytesB-cellBiopsyBlast CellBloodBlood Reticuloendothelial SystemBurkitt HerpesvirusBurkitt LymphomaBurkitt Lymphoma VirusBurkitt TumorBurkitt's Lymphoma/LeukemiaBurkitt's Type Small Non-Cleaved Cell LymphomaCDC47Cancer CauseCancer EtiologyCancersCell BodyCell CycleCell DeathCell Division CycleCell Growth in NumberCell LineCell MultiplicationCell NucleusCell ProliferationCellLineCellsCellular OncogeneCellular ProliferationCessation of lifeComplexDLBCLDNADNA HelicasesDNA ReplicationDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA mutationDNA replication forkDNA unwinding enzymeDeathDeoxyribonucleic AcidDependenceDevelopmentDiffuse Large B-Cell LymphomaDiseaseDisorderEB virusEBVEBV associated lymphomaEBV induced lymphomaEBV lymphomaEBV lymphoma cellEBV(+) lymphomaEBV+ lymphomaEBV+ve lymphomaEBV-positive lymphomasEBV-related lymphomaEnsureEpstein Barr VirusEpstein Barr Virus Associated LymphomaEpstein Barr Virus LymphomaEpstein Barr Virus driven lymphomaEpstein Barr Virus lymphoma cellEpstein Barr induced lymphomaEpstein-Barr Virus-Related LymphomaEventFormerly MCM2GenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGerminoblastic SarcomaGerminoblastomaGoalsHHV-4HHV4HIVHIV Associated LymphomaHIV LymphomaHIV-Related LymphomaHIV/AIDSHuman Herpesvirus 4Human Immunodeficiency VirusesImmuneImmune SurveillanceImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologic SurveillanceImmunosuppressed HostImmunosurveillanceImpairmentIndividualInfectionInfectious Mononucleosis VirusInfluentialsInvestigationJob's SyndromeKnowledgeLAV-HTLV-IIILinkLymphadenopathy-Associated VirusLymphomaLymphoma cellMCM7MCM7 geneMalignant CellMalignant LymphomaMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMechanicsModelingMorbidityMorbidity - disease rateMutationNon-Hodgkin's LymphomaNonhodgkins LymphomaNucleotidesNucleusOncogene ProductsOncogene ProteinsOncoproteinsPathway interactionsPatientsPersonsPhasePredispositionProliferatingPropertyProteinsProteomeProto-OncogenesPublic HealthReticulolymphosarcomaRiskRoleS PeriodS phaseSTAT3STAT3 geneSTAT3 loss of functionStrains Cell LinesStressSusceptibilitySynthesis PeriodSynthesis PhaseTestingTherapeuticTonsilTrans-Acting FactorsTrans-ActivatorsTransactivatorsTranscriptTranslatingTransplant RecipientsUpregulationViralViral LatencyVirusVirus LatencyVirus-HIVZinc Finger DomainZinc Finger MotifsZinc Fingersactivated B cellsantiretroviral therapyantiretroviral treatmentc-ONCcancer cellcancer microenvironmentcancer specimen resourcecell transformationchemotherapyclinical relevanceclinically relevantcultured cell linedevelopmentalexperiencegamma-herpesvirusgammaherpesvirusgenome mutationgenome scalegenome-widegenomewidehelicaseimmunosuppressedimmunosuppressed patientimproved outcomein vivoinfected B cellinfected B lymphocyteinnovateinnovationinnovativelarge cell Diffuse non-Hodgkin's lymphomalymphoblastoid cell linemalignancymechanicmechanicalmortalitynecrocytosisneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-Hodgkins diseasenovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoral pathogenpathwayprotooncogenerecruitreplication forkreplication stresssocial rolesynthetic lethal interactionsynthetic lethalitytonsillartransformed cellstransforming virustransplant patienttumor microenvironmentγ-herpesvirus
Description preview
PROJECT SUMMARY
Virus-associated lymphomas cause significant morbidity and mortality in HIV-infected individuals – indeed, the
oral pathogen Epstein-Barr virus (EBV) contributes to up to 90% of diffuse large B-cell lymphomas (DLBCL) and
40% of Burkitt lymphomas (BL). Although combined antiretroviral therapy (cART) and chemotherapy have
improved…
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