grant
Exploring the role, regulation, and antimicrobial function of Paneth cell peptides PYY and NPY in maintaining gut microbial commensalism and innate immune defense
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Apr 2017Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026Adenosine Deaminase-Binding ProteinsAffectAmphibiaAmphibiansAnti-Bacterial AgentsAscending colonBiochemicalBioinformaticsBlood SerumC albicansC. albicansC.albicansCD26CD26 AntigensCandida albicansCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCollaborationsCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDataDipeptidyl-Peptidase IVDiseaseDisorderDistal part of ileumDysfunctionEndocrineEnteric HormonesFunctional disorderGI commensalGI hormoneGI microbiotaGastrointestinal HormonesGastrointestinal microbiotaGene ExpressionGeneticGrantGranulomatous EnteritisHealthHepatic FlextureImmuneImmunesImmunologic FactorsImmunological FactorsIn VitroIntestinalIntestinal HormonesIntestinesInvestigationJournalsL CellsL-tyrosyl-L-tyrosineLamina PropriaLiquid substanceLysozymeMagazineMaintenanceMalasseziaMeasuresMediatingMediatorMicrobeMicrobiologyModificationMotionMucous body substanceMucusMuramidaseN-Acetylmuramide GlycanhydrolaseNeuropeptide TyrosinePYY PeptidePaneth CellsPeptide YYPeptidesPeptidoglycan N-acetylmuramoylhydrolasePhysiologicPhysiologicalPhysiologyPhysiopathologyPityrosporumPlayPopulationPredispositionProductivityPropertyRegulationRegulatory PathwayResearch ResourcesResourcesRoleSatiationScienceSecretory GranulesSecretory VesiclesSerumSignal PathwayStructureSubcellular ProcessSumSurfaceSusceptibilitySymbiosisTechnologyTerminal IleumTherapeutic FungicidesTransgenic MiceTyr-TyrVirulentYeastsanorexigenic peptideanti-bacterialanti-fungalanti-fungal agentsanti-fungal druganti-microbialanti-microbial peptideantimicrobialbacteria pathogenbacterial pathogenbeta-Defensinsbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbowelcommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensalismeleocolitisenteric commensalenteric microbial communityenteric microbiotaexperimentexperimental researchexperimental studyexperimentsfluidfungal pathogenfungi pathogenfungusgastrointestinal commensalgastrointestinal microbial floragut commensalgut communitygut dysbiosisgut floragut hormonegut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiotagut microbioticgut microfloragut-derived hormonehost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionsimmunologic substanceimmunological substancein vivoinsightintestinal commensalintestinal floraintestinal microbesintestinal microbiotaintestinal microfloraintestinal tract microfloraliquidmagaininmembermicrobialmucousmultidisciplinarymutantneuropeptide Ynovelpathobiontpathogenpathogenic bacteriapathogenic funguspathophysiologypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespeptide tyrosine-tyrosineprotein expressionregional enteritisrepurposingresponsesatietysocial roletyrosyltyrosinework groupworking groupβ-Defensins
Description preview
PROJECT SUMMARY/ABSTRACT
Innate immune factors are critical for the selection and maintenance of regional commensal gut microbiota that
provide beneficial functions for the host and deterrence against pathogens and pathobionts. In the previous grant
cycle, we discovered that peptide YY (PYY), an anorexigenic or satiety-related gut hormone of…
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