grant
Exploring O-glycoproteomics to prevent metabolic radioresistance in the tumor microenvironment
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Sept 2022Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAffectAnabolismBody TissuesCancer CauseCancer EtiologyCancer PatientCancersCaringCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeClinicalCo-cultureCocultivationCocultureCoculture TechniquesD-GlucoseDataDeathDevelopment PlansDextroseDiagnosisDiseaseDisorderEndotheliumEventFacultyFibroblastsFluorescenceFractionated radiotherapyGlucoseGlycansGlycobiologyGlycoproteinsGoalsHarvestHexosaminesImmuneImmunesImpairmentIn SituIn VitroIntracellular Communication and SignalingIntratumoral heterogeneityInvestigatorsLeadLung AdenocarcinomaLung NeoplasmsLung TumorMachine LearningMalignantMalignant - descriptorMalignant CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMentorsMesenchymalMetabolicMetabolic GlycosylationMetabolic MarkerMetabolic PathwayModelingModificationMolecular TargetNeighborhoodsOncogenesisOrganoidsOutcomeOutcome MeasurePathway interactionsPatientsPatternPb elementPhenotypePhosphorylationPolysaccharidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary NeoplasmPrimary TumorProtein GlycosylationProtein ModificationProtein PhosphorylationProtein RegionProteinsPulmonary CancerPulmonary NeoplasmsPulmonary malignant NeoplasmRadiationRadiation BiologyRadiation SensitivityRadiation ToleranceRadiation therapyRadiobiologyRadioresistanceRadiosensitivityRadiotherapeuticsRadiotherapyRefractoryResearch PersonnelResearch ResourcesResearchersResolutionResourcesRoleSignal TransductionSignal Transduction SystemsSignalingStromal CellsStromal NeoplasmStromal TumorStructureSystems BiologyTechniquesTestingTherapeuticThoracic OncologyTimeTissuesTreatment FailureVisualizationWorkassembloidsbio-computationbio-computingbiocomputationbiocomputingbiological signal transductionbiosynthesiscancer cellcancer cell metabolismcancer metabolismcancer microenvironmentcancer survivalcell behaviorcell dimensioncell typecellular behaviorglycoproteomicsglycosylationheavy metal Pbheavy metal leadheterogeneity in tumorsimage-based methodimaging methodimaging modalityimprovedin vivoinnovateinnovationinnovativeinsightintra-tumoral heterogeneityintratumor heterogeneitylung cancermachine based learningmalignancymeasurable outcomemultiplexed imagingneoplasm/cancernew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetoutcome measurementpathwaypreservationpreventpreventingradiation resistanceradiation resistantradiation treatmentradio resistanceradio-sensitivityradioresistantradiosensitiveresistant to radiationresolutionsresponse to therapyresponse to treatmentsocial rolesugarsurvival outcometenure processtenure tracktherapeutic responsetherapy failuretherapy responsethree dimensionaltooltreatment responsetreatment responsivenesstreatment with radiationtumortumor cell metabolismtumor heterogeneitytumor metabolismtumor microenvironmenttumorigenesis
Description preview
PROJECT SUMMARY
Radiotherapy (RT) is often the only curative option for patients with inoperable tumors. However, radiation is
also known to impair tumor metabolism, leading to radioresistance, the main reason for RT failure. Metabolic
reprogramming (MR) in cancer is defined as the ability of the tumor to rewire its energy to fulfill the needs for…
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