grant
Exploring modulation of Lamin A/C protein lifetime as a novel axis of regulation in heath and disease
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Apr 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AddressAffectBindingBiochemicalBody TissuesC proteinCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell NucleusConnective TissueCultured CellsDNA mutationDataDevelopmentDiseaseDisorderEmery-Dreifuss Muscular DystrophyEmery-Dreifuss SyndromeEmery-Dreifuss Type Muscular DystrophyEnvironmentFatsFatty acid glycerol estersFibroblast Intermediate Filament ProteinsFilamentGenesGenetic ChangeGenetic defectGenetic mutationGenomeGenotypeGoalsHealthHeart VascularHeterochromatinHutchinson-Gilford DiseaseHutchinson-Gilford SyndromeImpairmentIn SituIntermediate Filament ProteinsIsoformsLabelLamin ALamin Type ALaminsLettersLinkMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMechanicsMetabolicMetabolic Protein DegradationMolecular InteractionMuscleMuscle TissueMutationNuclearNuclear EnvelopeNuclear LaminNuclear Matrix ProteinsNuclear Matrix-Associated ProteinsNuclear MembraneNuclear Scaffold ProteinNucleusPeptide DomainPhenotypePhysiologicPhysiologicalPolymersPremature Senility SyndromeProductionProgeriaProtein CleavageProtein DomainsProtein IsoformsProtein TurnoverProteinsProteolysisProteomeProteomicsRegulationRegulatory Protein DegradationResearchSkeletal MuscleSkinSolubilityStructural ProteinStructureSyndromeTechniquesTertiary Protein StructureTestingTimeTissuesType V IF ProteinVoluntary Muscleaccelerated agingaccelerated biological ageaccelerated biological agingage accelerationbonecardiovascular disordercirculatory systemcitrate carriercitrate periplasmic carrier proteincitrate transportercitrate-binding transport proteincomputer based predictiondevelopmentalexperimentexperimental researchexperimental studyexperimentsgenome integritygenome mutationgenomic integrityhuman diseasein vivolamin Cmechanicmechanicalmouse modelmurine modelmuscularmutantnovelpolymerpolymericpredictive modelingprogramsprotein degradationprotein foldingprotein functionscaffoldscaffoldingtricarboxylate carriertricarboxylate transportertricarboxylate-binding C protein
Description preview
Summary / Abstract
The nuclear Lamins are intermediate filament proteins that underlie the nuclear envelope. Lamins assemble
into bundled filaments that strengthen the nucleus and scaffold the genome. The LMNA locus encodes the Lamin
A and C proteins; hundreds of mutations to LMNA have been linked to more than 10 distinct syndromes,
collectively…
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