grant
Exploring brain perivascular fibroblasts in health and cerebral amyloid angiopathy
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Aug 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years old2-photon microscopy21+ years oldAD dementiaAD pathologyAblationAccelerationAddressAdultAdult HumanAdventitial CellAdvisory CommitteesAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease pathologyAlzheimer's pathologyAlzheimer's precursor proteinAlzheimers DementiaAmyloidAmyloid A4 Protein PrecursorAmyloid Protein PrecursorAmyloid SubstanceAmyloid beta-Protein PrecursorAmyloid β-Protein PrecursorArteriesAstrocytesAstrocytusAstrogliaBiologyBlood Vessel ImagingBlood VesselsBlood flowBody TissuesBrainBrain Nervous SystemBrain VascularCalciumCalcium Ion SignalingCalcium SignalingCausalityCell BodyCellsCerebral Amyloid AngiopathyCerebrovascular systemChildChild YouthChildren (0-21)ClinicalClinical PathologyCommunicationComplexCongophilic AngiopathyCoupledDNA mutationDevelopmental BiologyDiameterDiseaseDisease ProgressionDisorderDysfunctionEncephalonEndothelial CellsEnsureEtiologyEventExpression SignatureExtracellular Matrix ProteinsFacultyFibroblastsFunctional disorderFutureGene Expression ProfileGene TranscriptionGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsHealthHypercapniaImageImpairmentInitiation FactorsInvestigationKnowledgeLeiomyocyteLifeMediatingMentorshipMethodsMiceMice MammalsMicrovascular DysfunctionModelingMurineMusMutationNeurovascular dysfunctionOpticsPathologyPathway interactionsPeptide Initiation FactorsPericapillary CellPericytesPerivascular CellPhasePhysiologyPhysiopathologyPopulationPrimary Senile Degenerative DementiaRNA ExpressionRegenerative MedicineReporterReportingResearchResearch InstituteRoleRouget CellsRunningSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellStructureTask ForcesTechniquesTestingTg2576TherapeuticTissuesTrainingTranscriptionTransgenic OrganismsTranslation Initiation FactorTranslational Initiation FactorVascular DiseasesVascular Disorderadulthoodadvisory teamamyloid precursor proteinarterioleastrocytic gliaawakeblood vessel disorderblood vessels in the brainbrain blood vesselsbrain healthbrain vasculaturecarbon dioxide retentioncareercausationcerebral blood vesselcerebral vascularcerebral vasculaturecerebro-vascularcerebrovascularcerebrovascular amyloidosiscerebrovascular vesselscerebrovasculatureconstrictiondevelop therapydisease causationelevated carbon dioxideexperiencegene expression patterngene expression signaturegenetic approachgenetic strategygenome mutationhypercarbiaimagingimaging in vivoimprovedin vivoin vivo imagingincreased level Carbon dioxideinnovateinnovationinnovativeintervention developmentkidsmicrovascular complicationsmicrovascular diseasemouse modelmurine modelneuro-vascularneuro-vascular couplingneuropathologicneuropathologicalneuropathologyneurovascularneurovascular abnormalityneurovascular couplingneurovascular dysregulationneurovascular impairmentneurovascular pathologyneurovasculopathyopticalpathophysiologypathwayprimary degenerative dementiasenile dementia of the Alzheimer typeskillssmall vessel diseasesocial roletherapy developmenttooltranscriptional profiletranscriptional signaturetranscriptomicstransgenictreatment developmenttwo photon excitation microscopytwo photon microscopyvascularvascular amyloidvascular componentvascular dysfunctionvascular factorvascular imagingvasculature Imagingvasculopathyvasomotionvenulewastingyoungster
Description preview
PROJECT SUMMARY
Maintaining a stable brain vascular network is crucial for ensuring overall brain health throughout life.
Perivascular cells, like pericytes and smooth muscle cells, are crucial to maintain the integrity of the brain
vasculature. Loss of pericytes and smooth muscle cells are noted in Alzheimer’s Disease (AD) and affects
vascular…
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