grant
Exploring activity-dependent regulation of intra and intercellular mitochondrial transport in astrocytes
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AD dementiaAccelerationActinsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal BehaviorAstrocytesAstrocytusAstrogliaBehaviorBindingBiologic ModelsBiological ModelsBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsCommunicationComplexCouplingCuesDataDegenerative Neurologic DisordersDendritesDevelopmentDiseaseDisorderDrosophilaDrosophila genusDysfunctionElectron MicroscopyEncephalonEnsureFliesFunctional disorderGenerationsGenesGeneticGenetic ScreeningGliaGlial CellsGoalsHumanImageImaging DeviceImaging InstrumentImaging ToolImpairmentIn VitroIntracellular Communication and SignalingKnowledgeKolliker's reticulumLength of LifeLinkLocationLocomotionLongevityMembraneMetabolicMicro-tubuleMicrotubulesMitochondriaModel SystemModern ManMolecularMolecular InteractionMonitorMotorMotor CellMotor NeuronsMovementMultivesicular BodyNerve CellsNerve DegenerationNerve Impulse TransmissionNerve TransmissionNerve UnitNervous SystemNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Body SystemNeurologic Degenerative ConditionsNeurologic Organ SystemNeuron DegenerationNeuronal TransmissionNeuronsNeuropilNon-neuronal cellNonneuronal cellOrganellesOxidative StressParalysis AgitansParkinsonParkinson DiseasePathologicPhysiopathologyPopulationPositionPositioning AttributePrimary ParkinsonismPrimary Senile Degenerative DementiaProcessRegulationRejuvenationRespirationRoleSignal TransductionSignal Transduction SystemsSignalingSiteSynapsesSynapticSystemTechniquesTestingTherapeuticTransgenic OrganismsVisualizationVisualization softwareaged brainaging brainastrocytic gliaaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbody movementcell typedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalexperimentexperimental researchexperimental studyexperimentsflyfruit flyglia signalingglial signalingimagingimprovedin vivoinnovateinnovationinnovativeknock-downknockdownlong-term memorymembrane structuremitochondrialmitochondrial dysfunctionmotoneuronnatural agingnerve cell metabolismnerve cementnerve signalingneural circuitneural circuitryneural degenerationneural networkneural signalingneurocircuitryneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuron cell metabolismneuron metabolismneuronalneuronal cell metabolismneuronal degenerationneuronal metabolismneuronal signalingneurotransmissionnormal agingnormative agingoptogeneticspathophysiologyprimary degenerative dementiarecruitrespiratory mechanismsenile dementia of the Alzheimer typesocial rolesynapsesynaptic circuitsynaptic circuitrytooltraffickingtransgenicvisualization tool
Description preview
PROJECT SUMMARY
Brain function is dependent on the precise wiring of distinct neuron types into functional neural circuits. Neurons
communicate with each other through synapses, which are carefully monitored and supported by specialized
non-neuronal cells called glia. Astrocytes are a prominent, peri-synaptic glial cell population that regulates…
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