grant
Exploring a Novel Myeloid Subset for Transporting Polyomavirus to the CNS
Organization PENNSYLVANIA STATE UNIV HERSHEY MED CTRLocation HERSHEY, UNITED STATESPosted 1 Dec 2025Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202512-20 years old19S Gamma Globulin21+ years old7S Gamma GlobulinAIDS/HIVAddressAdolescenceAdultAdult HumanAffectAlanyl AminopeptidaseAminopeptidase MAminopeptidase NAntigen-Presenting CellsAstrocytesAstrocytusAstrogliaAutoregulationB blood cellsB cellB cellsB-Cell DeficiencyB-CellsB-LymphocytesB-cellB7-1BB1BindingBloodBlood Precursor CellBlood Reticuloendothelial SystemBlood monocyteBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain VentricleCCL2CCL2 geneCD13CD13 AntigensCD28CD28 geneCD28LGCD28LG1CD80CD80 geneCD86CD86 geneCNS Nervous SystemCNS infectionCapsidCell BodyCell DeathCell LineCellLineCellsCentral Nervous SystemCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderCerebral VentriclesChemokine Receptor GeneChemokine, CC Motif, Ligand 2Choroid PlexusChoroid Plexus EpitheliumClass II GenesDNA cassetteDNA mutationDataDemyelinationsDomestic HorseDoseEncephalonEncephalon DiseasesEpendymaEpendymal CellEpendymal TissueEpendymocyteEpithelial CellsEquineEquine SpeciesEquus caballusEquus przewalskiiFellowshipFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFluorescence Activated Cell Sorting FractionationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsGenetic ChangeGenetic defectGenetic mutationGrafting ProcedureHIV/AIDSHLA Class II GenesHematogenousHematopoietic Progenitor CellsHematopoietic stem cellsHomeHomeostasisHorsesHumanIMiDIgGIgMImageImmune modulatory therapeuticImmune responseImmunocompetentImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunofluorescence MicroscopyImmunoglobulin GImmunoglobulin MImmunosuppressed HostImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroIndividualInfectionIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvadedJC PolyomavirusJC Polyomavirus EncephalitisJC Polyomavirus EncephalopathyJC VirusKidneyKidney Urinary SystemLAB7LaboratoriesLesionLigandsLong-term infectionMCAFMCP-1MCP1MHC Class IIMHC Class II GenesMacrophageMarrow monocyteMature B-CellMature B-LymphocyteMediatingMembrane Alanyl AminopeptidaseMessenger RNAMiceMice MammalsModelingModern ManMolecular InteractionMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMurineMusMutationMyelogenousMyeloidMyeloid CellsMφNeuraxisOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOrgan TransplantationOrgan TransplantsPatientsPhenotypePhysiological HomeostasisPolyomaPolyoma VirusesPolyomavirusPolyomavirus InfectionsPolyomavirus JCVPopulationPrimary InfectionProductivityProgenitor CellsProgressive Multifocal LeukoencephalopathyPublicationsPublishingRecombinantsReporterReportingRouteSCYA2Scientific PublicationSiteSmall Inducible Cytokine A2SolidSortingSourceSpleenSpleen Reticuloendothelial SystemStrains Cell LinesStructure of choroid plexusSurfaceT memory cellT44TestingTissuesTranscriptTravelUrinary tractViralVirionVirusVirus ParticleVirus ReplicationVisualizationWorkaccessory celladaptive immune responseadolescence (12-20)adulthoodalanine aminopeptidaseastrocytic gliablood cell progenitorblood progenitorblood stem cellblood-forming stem cellbrain parenchymacell typechemokine receptorchemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschronic infectioncultured cell linedemyelinateenhancer cassetteexpression cassetteextracellular vesiclesflow cytophotometryfluorophoregene cassettegenetic cassettegenome mutationhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhomeshost responsehumoral immunity deficiencyhypoimmunityimagingimmune competentimmune deficiencyimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulatory agentsimmune modulatory drugsimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunodeficiencyimmunomodulating agentsimmunomodulating drugsimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulatory agentsimmunomodulatory drugsimmunomodulatory therapeuticsimmunoresponseimmunosuppressed patientimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoin vivo Modelintegration cassettekidney epithelial cellmRNAmemory T lymphocytemigrationmonocytemouse polyomavirusmurine polyomavirusnecrocytosisneutralizing antibodynovelorgan allograftorgan graftorgan xenograftpathogenpersistent infectionpromoter cassetterenalreporter cassetteresistance cassetteresponseselectable cassetteselection cassetteseropositivespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cellsstop cassettesubstantia albatraffickingtranscription cassettetranscriptional cassettetransgene cassetteviral DNAviral multiplicationviral replicationvirus DNAvirus multiplicationwhite matter
Description preview
Abstract
JC polyomavirus (JCPyV) is the causative agent of the often-fatal demyelinating brain disease Progressive
multifocal leukoencephalopathy (PML). While 70-90% of adults carry JCPyV lifelong, only after
immunosuppression is the virus able to travel from the primary infection reservoir in the urinary tract to the
central nervous system. How…
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