grant
Exploiting symbiosis to identify novel antifungals to combat emerging drug-resistant pathogens
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AddressAllelesAllelomorphsAnimalsAntifungal TherapyAntsAssayBacteriaBacterial InfectionsBacterial natural productsBacterial-derived natural productBeetlesBioassayBiological AssayC albicansC aurisC. albicansC. aurisC.albicansCandida albicansCandida aurisClinicClinicalCo-cultureCocultivationCocultureCoculture TechniquesColeopteraCollectionCuesDataDevelopmentDiseaseDisease OutbreaksDisorderDrosophilaDrosophila genusDrug resistanceEnvironmentEpidemicExposure toFinding natural productsFluconazole resistanceFluconazole resistantFoundationsFungus DiseasesFutureGene ClusterGeneticGoalsHealthHivesHospitalsHumanInfectionLeadLibrariesLytotoxicityMethodsMiceMice MammalsMicrobeMicrobial BiofilmsModern ManMurineMusMycosesNatural ProductsNatural product discoveryNatural products from bacteriaNatureOrder ColeopteraOrganismOutbreaksPb elementPersonsPredispositionProductionPublic HealthRapid screeningResearchResearch ResourcesResistanceResistance to FluconazoleResourcesRouteSamplingSourceSquidSusceptibilitySymbiosisSystemTechniquesTherapeutic FungicidesToxic effectToxicitiesTunicataTunicatesUrochordataUrochordatesUrticariaWorkanti-fungalanti-fungal agentsanti-fungal drugantibiotic resistant pathogenattributable deathattributable mortalitybacteria infectionbacterial diseasebacterial microbiomebacteriomebiofilmclinical developmentcombatcommensalismcounterscreencytotoxicitydevelopmentaldrug developmentdrug resistantdrug resistant pathogeneggemerging pathogenentire genomeexperimentexperimental researchexperimental studyexperimentsfruit flyfull genomefungal geneticsfungal infectionfungal infectious disease treatmentfungal pathogenfungi pathogenfungusfungus infectiongenetic approachgenetic strategygenome profilinggenome sequencinggenomic profilinghealth care settingsheavy metal Pbheavy metal leadhospital careinnovateinnovationinnovativeliving systemmetabolism measurementmetabolomicsmetabonomicsmicrobiomenaturally occurring productnew pathogennovelnovel pathogenpathogenpathogenic fungusresistance strainresistance to Drugresistantresistant strainresistant to Drugresistant to fluconazoleresponsescreeningscreeningssea squirtsmall moleculesynergismtoolwhole genomeyeast genetics
Description preview
Project Summary
High levels of drug resistance is a defining feature of the emerging pathogen Candida auris and this is
associated with high levels of attributable mortality in ongoing hospital outbreaks, thus necessitating the
discovery of new antifungals. Bacteria are a potent source of antifungals, however, traditional routes for
antifungal…
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