grant
Exploiting differences in HPV oncoprotein function among oropharyngeal cancers to personalize therapy
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025Antioncogene Protein p53AntioxidantsBiogenesisBiological MarkersCDDPCancersCellular Tumor Antigen P53ChromatinChromatin Remodeling ComplexChromatin Remodeling FactorCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClinicalCysplatynaDependenceDichlorodiammineplatinumDiseaseDisease ProgressionDisorderDistant CancerDistant MetastasisEnzyme GeneEnzymesFutureGeneralized GrowthGenesGrowthHPVHPV E6HPV associated OPSCCHPV caused cancerHPV driven cancersHPV induced cancerHPV malignancyHPV positive OPSCCHPV positive oropharyngeal squamous cell carcinomaHPV related OPSCCHPV related oropharyngeal squamous cell carcinomaHPV+ OPSCCHPV+ cancerHPV+ oropharyngeal squamous cell carcinomaHPV-Related MalignancyHPV-associated cancerHPV-associated malignancyHPV-related cancerHuman Papilloma VirusHuman Papilloma Virus-Related MalignancyHuman Papilloma Virus-Related Malignant NeoplasmHuman Papilloma Virus-associated cancerHuman Papilloma Virus-associated malignancyHuman Papilloma Virus-related cancerHuman PapillomavirusHuman papillomavirus cancerHuman papillomavirus induced cancerHuman papillomavirus malignancyHuman papillomavirus-Related MalignancyHuman papillomavirus-Related Malignant NeoplasmHypoxiaHypoxicIndividualInfectious Human Wart VirusIntermediary MetabolismInterventionInvadedKnowledgeLifelong disabilityMalignant CellMalignant NeoplasmsMalignant Oropharyngeal NeoplasmMalignant Oropharyngeal TumorMalignant TumorMediatingMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMitochondriaModelingMolecularMolecular TargetNeoplasm MetastasisNutrient DepletionOncogene ProductsOncogene ProteinsOncogenicOncoprotein p53OncoproteinsOrigin of LifeOropharnyx CancersOropharyngeal CancerOropharyngeal CarcinomaOropharyngeal Epidermoid CarcinomaOropharyngeal Squamous Cell CarcinomaOropharynx CancerOropharynx CarcinomaOxidative StressOxidative Stress InductionOxygen DeficiencyP53Papillomavirus Transforming Protein E6Pathway interactionsPatientsPermanent disabilityPeyrone's ChloridePeyrone's SaltPhenocopyPhosphoprotein P53Phosphoprotein pp53Platinum DiamminodichlorideProtein TP53ProteinsRadiationRadiation DoseRadiation Dose UnitRecurrenceRecurrentRepressionResistanceRiskRoleSecondary NeoplasmSecondary TumorSurvivorsSystemTP53TP53 geneTRP53TestingTherapeuticThroat CancerThroat CarcinomaTissue GrowthToxic effectToxicitiesTreatment FailureTreatment-related toxicityTumor CellTumor Protein p53Tumor Protein p53 GeneViral Gene ProductsViral Gene ProteinsViral Protein E6Viral Proteinsbio-markersbiologic markerbiomarkercancer cellcancer metastasiscancer progressioncancer typechromatin modifiercis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumcustomized therapycustomized treatmentdisabilityeffective therapyeffective treatmenthigh riskhuman papilloma virus oropharyngeal squamous cell carcinomahuman papilloma virus+ oropharyngeal squamous cell carcinomahuman papillomavirus E6 oncoproteinhuman papillomavirus associated malignancyhuman papillomavirus associated oropharyngeal squamous cell carcinomahuman papillomavirus associated oropharynx squamous cell carcinomahuman papillomavirus caused cancerhuman papillomavirus driven cancershuman papillomavirus positive oropharyngeal squamous cell carcinomahuman papillomavirus related oropharyngeal squamous cell carcinomahuman papillomavirus-associated cancerhuman papillomavirus-related cancerindividual patientindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentineffective therapiesineffective treatmentintervention designirradiation responsemalignancymalignant oropharynx neoplasmmalignant oropharynx tumormitochondrialneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionontogenyoropharynx epidermoid carcinomaoropharynx squamous cell carcinomaover-treatmentovertreatmentp53 Antigenp53 Genesp53 Tumor Suppressorpapilloma virus Transforming Protein E6pathwaypatient specific therapiespatient specific treatmentpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpreservationpreventpreventingprospectiveprotein p53radiation responseresistance to therapyresistantresistant to therapyresponse to radiationresponse to therapyresponse to treatmentrisk stratificationsocial rolestandard carestandard treatmentstratify risktailored medical treatmenttailored therapytailored treatmenttherapeutic resistancetherapeutic responsetherapeutic toxicitytherapy associated toxicitytherapy designtherapy failuretherapy related toxicitytherapy resistanttherapy responsetherapy toxicitytooltreatment designtreatment resistancetreatment responsetreatment responsivenesstreatment toxicitytreatment-associated toxicitytumortumor cell metastasistumor progressionunique treatmentvirus proteinwart virus
Description preview
PROJECT SUMMARY
Toxicities of treating human papilloma virus-related (HPV+) oropharyngeal squamous cell carcinomas
(OPSCCs) with radiation plus cisplatin create lifelong disabilities in survivors of this increasingly common
cancer. Reducing radiation doses and cisplatin use for HPV+ OPSCC is impeded by difficulty distinguishing a
subset of cases…
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