grant
Experimental Animal Models of TB: Chemotherapeutics and Imaging
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY202518-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2-Fluoro-2-deoxyglucoseAdvanced DevelopmentAfter CareAfter-TreatmentAftercareAirAnimal ModelAnimal Models and Related StudiesAnimalsAntibiotic AgentsAntibiotic DrugsAntibioticsAntitubercular AgentsAntitubercular DrugsAssayBCG immunizationBCG vaccinationBCG-vaccinatedBacille Calmette-Guerin vaccinatedBacille Calmette-Guerin vaccinationBacillus Calmette-Guerin vaccinationBacillus Calmette-Guérin vaccinationBacteriaBarberingBenchmarkingBest Practice AnalysisBioassayBiological AssayBody TissuesCAT scanCT X RayCT XrayCT imagingCT scanCallithrixCell Communication and SignalingCell SignalingCellular biologyClinical ResearchClinical StudyClinical TrialsClinical assessmentsCollaborationsComputed TomographyDetectionDevelopmentDiffusionDisablingDiseaseDisease ProgressionDisorderDomestic RabbitDoseDouble-Stranded DNADrug KineticsDrug TherapyDrugsEukaryotic CellExperimental Animal ModelExposure toFluoroquinolonesFoundationsFrequenciesFunctional ImagingGenus MycobacteriumGoalsGranulomaGranulomatous LesionHapaleHourHumanImageImaging ProceduresImaging TechnicsImaging TechniquesImmunochemical ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologicImmunologicalImmunologicallyImmunologicsImmunologistImmunologyIncubatedIndividualInfectionIntermediary MetabolismIntracellular Communication and SignalingKO miceKineticsKnock-out MiceKnockout MiceKnowledgeLabelLesionLipidsM mulattaM tbM tuberculosisM tuberculosis infectionM. mulattaM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacaca mulattaMacaca rhesusMaintenanceMapsMarmosetsMeasuresMediatingMedicationMetabolic ProcessesMetabolismMiceMice MammalsMiscellaneous AntibioticModelingModern ManModernizationMonitorMurineMusMycobacteriumMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNHP modelsNecrosisNecroticNitroimidazolesNull MouseOryctolagus cuniculusOutcomePETPET ScanPET imagingPETSCANPETTPathogenicity FactorsPathologyPenetrationPersonsPharmaceutical PreparationsPharmacokineticsPharmacological TreatmentPharmacotherapyPhysiologic ImagingPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPre-Clinical ModelPreclinical ModelsProductionPublicationsRabbitsRabbits MammalsRad.-PETRegimenRelapseReporterReportingResistance developmentResistant developmentRhesus MacaqueRhesus MonkeyRoleScientific PublicationScientistShort-Tusked MarmosetSignal TransductionSignal Transduction SystemsSignalingSpatial DistributionT-CellsT-LymphocyteTB chemotherapyTB drugsTB infectionTB therapyTB treatmentTechniquesTechnologyTestingTherapeuticTimeTissuesTomodensitometryTracerTreatment ProtocolsTreatment RegimenTreatment ScheduleTrehaloseTuberculosisTuberculostatic AgentsVaccinatedVascular blood supplyVirulence FactorsWorkX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyanti-TBanti-TB drugsanti-tuberculosisanti-tuberculosis drugsantiTBantigen-specific T cellsbacteria metabolismbacterial metabolismbenchmarkbiological signal transductionblack holeblood supplycatscancell biologychemotherapycomputed axial tomographycomputer based predictioncomputer tomographycomputerized axial tomographycomputerized tomographydetection limitdeveloping resistancedevelopmentaldiffuseddiffusesdiffusingdiffusionsdisseminated TBdisseminated tuberculosisdrug candidatedrug detectiondrug distributiondrug efficacydrug interventiondrug testingdrug treatmentdrug/agentds-DNAdsDNAenzyme activityexperienceexperimentexperimental researchexperimental studyexperimentsfluorodeoxyglucosehuman dataimagingimprovedin vitro Assayin vivoinfection due to Mycobacterium tuberculosisinflammation markerinflammatory markerinhibitorlaser capture microdissectionmodel of animalmtbnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generationnext generation therapeuticsnon vaccinatednon-contrast CTnoncontrast CTnoncontrast computed tomographynonhuman primate modelsnot vaccinatednovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphysiological imagingpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost treatmentpredictive modelingquinolineradiolabelradiolabelsradiotracerrational designresponseresponse to therapyresponse to treatmentsecondary metabolitesimulationsmall moleculesocial rolespatial and temporalspatial temporalspatiotemporalstructural imagingtherapeutic responsetherapy responsethymus derived lymphocytetreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistreatment effecttreatment responsetreatment responsivenesstuberculosis chemotherapytuberculosis drugstuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyunvaccinateduptakevascular supply
Description preview
This project encompasses approaches to understand how current anti-tubercular chemotherapy works using modern technologies and to develop new and improved therapies and therapeutic approaches. Individual projects within this framework are (1) developing structural and functional imaging techniques using PET/CT for use in live, M. tuberculosis…
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